Treatment of Pediatric IgG4-Related Orbital Disease With TNF-α Inhibitor
Related Experiment Video
Updated: Feb 26, 2026

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats
Published on: May 23, 2025
Sanjai Jalaj1, Kristen Dunbar, Ashley Campbell
1Columbia University Medical Center/Harkness Eye Institute, New York, New York, U.S.A.
Abstract:
The authors describe a 9-year-old female who presented with swelling, proptosis, and tenderness of the right upper eyelid and MRI imaging demonstrating right lacrimal gland enlargement. After failing treatment with corticosteroids, the patient underwent a biopsy that was consistent with IgG4-related orbital disease. She was subsequently successfully treated with adalimumab (TNF-α inhibitor). This is the first case report of the successful use of a TNF-α inhibitor for the treatment of IgG4-related orbital disease in a child.
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