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Related Experiment Videos

Aortic baroreceptor deafferentation in the baboon.

V S Bishop, J R Haywood, R E Shade

    Journal of Applied Physiology (Bethesda, Md. : 1985)
    |March 1, 1986
    PubMed
    Summary

    Removing aortic baroreceptors in baboons increased arterial pressure and heart rate. This suggests reduced heart rate baroreflex sensitivity and heightened sympathetic nervous system activity.

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    Area of Science:

    • Cardiovascular Physiology
    • Neuroscience

    Background:

    • Aortic baroreceptors help regulate blood pressure.
    • Their role in conscious nonhuman primates was previously unexamined.

    Purpose of the Study:

    • To investigate the function of aortic baroreceptors in conscious baboons.
    • To determine their role in arterial pressure and heart rate regulation.

    Main Methods:

    • Adult male baboons were studied using a chronic tether system for free movement.
    • Arterial pressure and heart rate were monitored continuously over 24-hour periods.
    • Cardiovascular function was tested with periodic drug administration.

    Main Results:

    • Aortic baroreceptor removal increased arterial pressure (85.6 to 104.6 mmHg) and heart rate (77.5 to 117.9 bpm).
    • The arterial pressure-heart period relationship sensitivity decreased.
    • The depressor response to ganglionic blockade was augmented.

    Conclusions:

    • Aortic baroreceptors are crucial for maintaining normal arterial pressure and heart rate regulation in baboons.
    • Their removal leads to reduced heart rate baroreflex sensitivity.
    • This contributes to increased arterial pressure via enhanced sympathetic nervous system function.

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