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Cerebrovascular risk factors for patients with cerebral watershed infarction: A case-control study based on computed

Mei-Xue Dong1, Ling Hu, Yuan-Jun Huang

  • 1Department of Neurology, The First Affiliated Hospital of Chongqing Medical University Department of Neurology, The Fifth People's Hospital of Chongqing, Chongqing, China.

Medicine
|July 13, 2017
PubMed

Insights

Cerebral watershed infarction (CWI) risk factors were identified in Southwest China. Stenosis in the ipsilateral middle cerebral artery, carotid artery, and contralateral middle cerebral artery are key risks for internal CWI.

Area of Science:

  • Neurology
  • Vascular Neurology
  • Stroke Research

Background:

  • Cerebral watershed infarction (CWI) is a type of ischemic stroke.
  • Identifying specific cerebrovascular risk factors is crucial for targeted prevention and treatment.

Purpose of the Study:

  • To investigate the cerebrovascular risk factors associated with internal CWI (I-CWI) and external CWI (E-CWI) in a Southwest China population.
  • To determine independent risk factors for different types of CWI.

Main Methods:

  • Patients with acute ischemic stroke were classified into I-CWI, E-CWI, or non-CWI groups.
  • Clinical data and degrees of arterial steno-occlusion were assessed, including the circle of Willis.
  • Multivariate binary logistic regression analysis was employed to identify independent risk factors.

Main Results:

  • I-CWI was significantly associated with higher degrees of steno-occlusion in the ipsilateral middle cerebral artery, ipsilateral carotid artery, and contralateral middle cerebral artery compared to non-CWI.
  • The ipsilateral middle cerebral artery, carotid artery, and contralateral middle cerebral artery were confirmed as independent risk factors for I-CWI.
  • No significant cerebrovascular risk factors were identified for E-CWI.
  • No significant differences were observed in arteries associated with the circle of Willis among the groups.

Conclusions:

  • Stenosis of the ipsilateral middle cerebral artery, carotid artery, and contralateral middle cerebral artery are independent risk factors for internal cerebral watershed infarction.
  • Further research may be needed to elucidate risk factors for external cerebral watershed infarction.

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