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Studies on metronidazole tablet formulations.

O A Itiola, N Pilpel

The Journal of Pharmacy and Pharmacology

|February 1, 1986

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Adding binders like polyvinylpyrrolidone, gelatin, and methylcellulose to metronidazole tablets affects tablet strength, disintegration, and dissolution. These changes are linked to reduced water wettability and binder concentration.

Area of Science:

Pharmaceutical Sciences
Materials Science

Background:

Tablet formulation is critical for drug delivery.
Binders influence tablet properties like disintegration and dissolution.

Purpose of the Study:

To investigate the impact of different binding agents on metronidazole tablet characteristics.
To establish correlations between binder type, wettability, and drug release.

Main Methods:

Tablets were formulated with polyvinylpyrrolidone, gelatin, and methylcellulose.
Tensile strength, disintegration, and dissolution times were measured.
Wettability was assessed using adhesion tension of water.

Main Results:

Binders altered tablet tensile strength, disintegration, and dissolution.

Related Experiment Videos

Reduced wettability (higher adhesion tension) correlated with altered disintegration and dissolution.

Correlations were dependent on binder type and concentration.

Conclusions:

Binder selection significantly impacts metronidazole tablet performance.
Wettability is a key factor influencing tablet disintegration and dissolution rates.
Understanding these correlations aids in optimizing tablet formulations.