Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Diversity in Cell Signaling Responses

Diversity in Cell Signaling Responses

The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity.
Graded and Abrupt Responses
Some signaling systems generate...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Gravity as a Boundary Condition for the Evolution of Three-Dimensional Multicellularity.

Life (Basel, Switzerland)·2026

Same author

Sex Representation and User Preferences in Pain Drawing Body Charts in Back Pain Research: Multimethod Study.

JMIR human factors·2026

Same author

Plasma Adsorption Perfusion (BR-350) Versus Open Albumin Dialysis (OPAL) for Hyperbilirubinemia in Hepatic Failure in Cirrhotic Patients.

Artificial organs·2026

Same author

IL-1 receptor antagonist as a diagnostic biomarker for bacterial infections in acute decompensation of cirrhosis.

Scientific reports·2025

Same author

Serum IL-17F as a biomarker of infection-independent cirrhosis progression.

Frontiers in immunology·2025

Same author

Dynamic ultrasound guided assessment of pelvic ring injury measurement (PRIME) for traumatic symphysis diastasis.

European journal of trauma and emergency surgery : official publication of the European Trauma Society·2025

Search research articles

Related Experiment Video

Updated: Feb 26, 2026

Culturing Lymphocytes in Simulated Microgravity Using a Rotary Cell Culture System

Culturing Lymphocytes in Simulated Microgravity Using a Rotary Cell Culture System

Published on: August 25, 2022

Dynamic gene expression response to altered gravity in human T cells.

Cora S Thiel^1,2, Swantje Hauschild^3,4, Andreas Huge⁵

¹Institute of Anatomy, Faculty of Medicine, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland. cora.thiel@uzh.ch.

Scientific Reports

|July 14, 2017

Summary

Human T cells rapidly adapt to altered gravity, with gene expression changing within seconds and minutes. Key gravity-regulated genes identified include ATP6V1A/D, IGHD3 genes, and LINC00837, highlighting robust cellular adaptation mechanisms.

More Related Videos

Reduced-gravity Environment Hardware Demonstrations of a Prototype Miniaturized Flow Cytometer and Companion Microfluidic Mixing Technology

Reduced-gravity Environment Hardware Demonstrations of a Prototype Miniaturized Flow Cytometer and Companion Microfluidic Mixing Technology

Published on: November 13, 2014

Chondrogenic Differentiation Induction of Adipose-derived Stem Cells by Centrifugal Gravity

Chondrogenic Differentiation Induction of Adipose-derived Stem Cells by Centrifugal Gravity

Published on: February 24, 2017

Related Experiment Videos

Last Updated: Feb 26, 2026

Culturing Lymphocytes in Simulated Microgravity Using a Rotary Cell Culture System

Culturing Lymphocytes in Simulated Microgravity Using a Rotary Cell Culture System

Published on: August 25, 2022

Reduced-gravity Environment Hardware Demonstrations of a Prototype Miniaturized Flow Cytometer and Companion Microfluidic Mixing Technology

Reduced-gravity Environment Hardware Demonstrations of a Prototype Miniaturized Flow Cytometer and Companion Microfluidic Mixing Technology

Published on: November 13, 2014

Chondrogenic Differentiation Induction of Adipose-derived Stem Cells by Centrifugal Gravity

Chondrogenic Differentiation Induction of Adipose-derived Stem Cells by Centrifugal Gravity

Published on: February 24, 2017

Area of Science:

Space biology
Cellular biology
Genomics

Background:

Gene expression dynamics in human cells under altered gravity are not fully understood.
Understanding cellular responses to gravity is crucial for space exploration and human health.

Purpose of the Study:

To investigate the immediate and initial gene expression response of human Jurkat T cells to different gravitational environments.
To identify potential gravity-regulated genes and cellular adaptation processes.

Main Methods:

Utilized Affymetrix GeneChip® Human Transcriptome Array 2.0 for comprehensive gene expression profiling.
Conducted experiments during parabolic flight and suborbital ballistic rocket missions for cross-validation.
Employed rigorous control experiments to isolate the effects of altered gravity.

Main Results:

Human T cells exhibited rapid gene expression responses to altered gravity within 20 seconds and 5 minutes.
Initial microgravity response primarily involved regulatory RNAs.
Identified and cross-validated three gravity-regulated genes: ATP6V1A/D (V-ATPase), IGHD3-3/IGHD3-10 (immunoglobulin genes), and LINC00837 (long non-coding RNA).

Conclusions:

Human cells possess a robust and efficient adaptation potential to altered gravitational environments.
Rapid and extensive gene expression alterations, particularly involving regulatory RNAs, underscore this adaptive capacity.