Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Feb 26, 2026

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation
06:50

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation

Published on: June 10, 2020

2.3K

Microglial Activation in Traumatic Brain Injury.

Cornelius K Donat1, Gregory Scott1, Steve M Gentleman1

  • 1Division of Brain Sciences, Department of Medicine, Imperial College LondonLondon, United Kingdom.

Frontiers in Aging Neuroscience
|July 14, 2017
PubMed
Summary

Microglia activation after traumatic brain injury (TBI) has complex roles. Early activation aids recovery, but chronic activation causes damage, highlighting the need for targeted therapies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

New onset refractory status epilepticus (NORSE) versus refractory status epilepticus not meeting NORSE criteria: A comparative clinical and electroencephalography-based study.

Epilepsia·2026
Same author

Cortical synchrony is reduced in Alzheimer's disease and relates to arousal state.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Network-based disease fingerprinting with neuroinflammation PET imaging.

Journal of neuroinflammation·2026
Same author

Synthesis and preclinical evaluation of FAP-targeting radiotracers for PET and optical imaging.

EJNMMI radiopharmacy and chemistry·2025
Same author

In Vitro Characterization of the Published Glypican-3-Targeting Peptide TJ12P2 Reveals a Lack of Specificity and Potency.

Pharmaceuticals (Basel, Switzerland)·2025
Same author

Network-based disease fingerprinting with neuroinflammation PET imaging.

Research square·2025

Area of Science:

  • Neuroscience
  • Immunology
  • Cell Biology

Background:

  • Microglia are key immune cells in the central nervous system (CNS).
  • Microglia activation is rapid following CNS damage like traumatic brain injury (TBI).
  • Microglia exhibit diverse activation states influencing brain repair and neurodegeneration.

Purpose of the Study:

  • To review the dynamic role of microglia in TBI.
  • To analyze microglia distribution, morphology, and function over time in TBI models.
  • To explore therapeutic strategies targeting microglial activation phenotypes.

Main Methods:

  • Review of animal studies with genetic and pharmacological microglia manipulation.
  • Analysis of human and animal TBI studies.
  • Description of in vivo imaging techniques like TSPO PET and autoradiography.
Keywords:
CCITSPOmicroglianeuroinflammationpolarization statestraumatic brain injury

More Related Videos

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
07:21

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Published on: May 27, 2022

3.7K
Controlled Cortical Impact Model for Traumatic Brain Injury
05:30

Controlled Cortical Impact Model for Traumatic Brain Injury

Published on: August 5, 2014

29.8K

Related Experiment Videos

Last Updated: Feb 26, 2026

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation
06:50

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation

Published on: June 10, 2020

2.3K
Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
07:21

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Published on: May 27, 2022

3.7K
Controlled Cortical Impact Model for Traumatic Brain Injury
05:30

Controlled Cortical Impact Model for Traumatic Brain Injury

Published on: August 5, 2014

29.8K

Main Results:

  • Microglia activation patterns vary significantly post-TBI.
  • Activated microglia can be found remotely from injury sites.
  • Early microglial activation may promote homeostasis, while chronic activation can lead to neurodegeneration.

Conclusions:

  • The classification of microglial activation states is complex and context-dependent.
  • Understanding temporal microglial dynamics is crucial for TBI treatment.
  • Targeting microglia to promote beneficial phenotypes offers a promising therapeutic avenue for TBI.