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Renal Oxygenation in the Pathophysiology of Chronic Kidney Disease

Zhi Zhao Liu1, Alexander Bullen1, Ying Li1

  • 1Division of Nephrology-Hypertension, University of California San Diego School of Medicine, VA San Diego Healthcare SystemSan Diego, CA, United States.

Frontiers in Physiology
|July 14, 2017
PubMed

Insights

Chronic kidney disease (CKD) involves impaired renal oxygenation. This review explores how oxygen delivery, consumption, and tension change in diabetic and hypertensive CKD, examining mechanisms and therapies.

Area of Science:

  • Nephrology
  • Physiology
  • Pathophysiology

Background:

  • Chronic kidney disease (CKD) presents a major global health challenge with substantial morbidity and mortality.
  • Current therapeutic strategies for CKD, particularly in diabetic and hypertensive cases, are limited, focusing primarily on blood pressure, glycemic control, and proteinuria reduction.
  • Renal oxygenation has emerged as a critical factor in understanding CKD progression.

Purpose of the Study:

  • To review alterations in renal oxygenation (delivery, consumption, tissue oxygen tension) in pre-clinical and clinical studies of diabetic and hypertensive CKD.
  • To elucidate the underlying mechanisms driving these oxygenation changes.
  • To discuss potential therapeutic avenues targeting renal oxygenation.

Main Methods:

  • Comprehensive review of pre-clinical and clinical studies.
  • Analysis of data on renal oxygen delivery, consumption, and tissue oxygen tension.
  • Examination of the physiological and pathophysiological mechanisms involved.

Main Results:

  • Significant alterations in renal oxygenation are observed in diabetic and hypertensive CKD.
  • Understanding the determinants and regulators of renal oxygenation is advancing.
  • These alterations are linked to disease progression and offer potential therapeutic targets.

Conclusions:

  • Renal oxygenation plays a crucial role in the pathophysiology of diabetic and hypertensive CKD.
  • Targeting renal oxygenation presents a promising strategy for future therapeutic interventions.
  • Further research into renal oxygenation mechanisms could lead to novel treatments for CKD.

Keywords:
AMPKchronic kidney disease pathophysiologyhypoxiahypoxia inducible factor (HIF)renal oxygen consumption

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