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Related Concept Videos

Major Somatic Sensory Pathways01:28

Major Somatic Sensory Pathways

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Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
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Cerebellum: Anatomical Regions01:17

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The cerebellum, also known as the "little brain," is located in the posterior cranial fossa, inferior to the tentorium cerebelli and dorsal to the brainstem. It plays a significant role in motor control, coordination, and proprioception.
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Disorders of the Skeletal Muscle01:28

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Role of Cerebellum and Prefrontal Cortex in Memory01:14

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The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
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Indirect Motor Pathways

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The indirect motor or extrapyramidal pathways originate in the brainstem, the lower portion of the brain that connects it to the spinal cord. They consist of several distinct tracts, each with specialized functions. The four main tracts of the indirect motor pathways are the vestibulospinal tract, the reticulospinal tract, the tectospinal tract, and the rubrospinal tract.
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Updated: Feb 26, 2026

Cerebellar Regional Dissection for Molecular Analysis
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Cerebellar Dysfunction in Multiple Sclerosis.

Alastair Wilkins1

  • 1MS and Stem Cell Group, University of Bristol, Learning and Research, Southmead Hospital, Bristol, United Kingdom.

Frontiers in Neurology
|July 14, 2017
PubMed
Summary
This summary is machine-generated.

Multiple sclerosis commonly impacts the cerebellum, causing debilitating symptoms like tremor and ataxia. Future research into cerebellar disease pathophysiology offers hope for improved treatment of these difficult multiple sclerosis symptoms.

Keywords:
ataxiacerebellar diseasesdemyelinating diseasesmultiple sclerosispurkinje cells

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Area of Science:

  • Neuroscience
  • Neurology
  • Immunology

Background:

  • Multiple sclerosis (MS) frequently affects the cerebellum, leading to both acute and chronic neurological symptoms.
  • Cerebellar dysfunction in MS significantly contributes to patient disability.
  • Symptoms like tremor, ataxia, and dysarthria associated with cerebellar MS are challenging to manage effectively.

Purpose of the Study:

  • To review the current understanding of cerebellar disease in multiple sclerosis.
  • To highlight the impact of cerebellar symptoms on disability in MS patients.
  • To discuss the potential for future therapeutic advancements based on ongoing research.

Main Methods:

  • Review of human postmortem studies on cerebellar pathology in MS.
  • Analysis of experimental models of cerebellar disease in MS.
  • Examination of clinical trial data related to cerebellar symptoms in MS.

Main Results:

  • Cerebellar involvement is a common and significant feature of multiple sclerosis.
  • Specific symptoms such as tremor, ataxia, and dysarthria pose major treatment challenges.
  • Advances in understanding pathophysiology are paving the way for novel therapeutic strategies.

Conclusions:

  • Cerebellar pathology is central to the disability experienced by many individuals with MS.
  • Improved understanding of the underlying mechanisms of cerebellar MS is crucial.
  • There is optimism for enhanced future treatments targeting cerebellar symptoms in MS.