Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intravenous nutrition and hepatic dysfunction.

J F Robertson, O J Garden, A Shenkin

    JPEN. Journal of Parenteral and Enteral Nutrition
    |March 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    An architectural understanding of natural sway frequencies in trees.

    Journal of the Royal Society, Interface·2019
    Same author

    Defining malnutrition: A plea to rethink.

    Clinical nutrition (Edinburgh, Scotland)·2016
    Same author

    The nature of the association between parental rejection and delinquent behavior.

    Journal of youth and adolescence·2013
    Same author

    Identification of alkaptonuria in the general population: a United Kingdom experience describing the challenges, possible solutions and persistent barriers.

    Journal of inherited metabolic disease·2011
    Same author

    ESPEN Guidelines on Parenteral Nutrition: geriatrics.

    Clinical nutrition (Edinburgh, Scotland)·2009
    Same author

    Micronutrient concentrations in respiratory syncytial virus and human metapneumovirus in Yemeni children.

    Annals of tropical paediatrics·2009
    Same journal

    Association between GLIM-defined malnutrition and in-hospital costs in adults with sepsis: A sub analysis of a prospective cohort study.

    JPEN. Journal of parenteral and enteral nutrition·2026
    Same journal

    Postoperative body mass index and the risk of unfavorable outcomes in adults following esophagectomy for esophageal cancer: A retrospective cohort study.

    JPEN. Journal of parenteral and enteral nutrition·2026
    Same journal

    Characterization of patients with medically unexplained intolerance to enteral feeding treated with home parenteral nutrition: A descriptive cohort study.

    JPEN. Journal of parenteral and enteral nutrition·2026
    Same journal

    Association between blood phosphorus level and clinical outcomes in critically ill patients: A systematic review and meta-analysis.

    JPEN. Journal of parenteral and enteral nutrition·2026
    Same journal

    Decreased bone mineral density in adults with type 2 intestinal failure: A descriptive cross-sectional study.

    JPEN. Journal of parenteral and enteral nutrition·2026
    Same journal

    JPEN Journal Club 102. The Hochberg Procedure.

    JPEN. Journal of parenteral and enteral nutrition·2026
    See all related articles

    Intravenous nutrition can cause liver function abnormalities, with gamma-glutamyl transpeptidase being the most sensitive indicator. Malnourished patients and those with sepsis or significant blood transfusions are at higher risk for these liver changes.

    Area of Science:

    • Biochemistry
    • Hepatology
    • Surgical Nutrition

    Background:

    • Intravenous nutrition (IVN) is crucial for surgical patients unable to meet nutritional needs orally.
    • Liver function abnormalities are a known complication of IVN, but specific biochemical markers and risk factors require further elucidation.

    Purpose of the Study:

    • To review biochemical liver function test (LFT) abnormalities in general surgical patients receiving IVN.
    • To identify the most sensitive LFT marker for liver dysfunction during IVN.
    • To assess the impact of sepsis, blood transfusions, and nutritional status on LFTs in these patients.

    Main Methods:

    • Retrospective study analyzing LFTs of 26 general surgical patients with normal baseline LFTs undergoing IVN.
    • Monitoring of liver enzymes including gamma-glutamyl transpeptidase, alkaline phosphatase, bilirubin, aspartate aminotransferase, and alanine aminotransferase.

    Related Experiment Videos

  • Correlation of LFT abnormalities with clinical factors such as sepsis and blood transfusion volume, and baseline anthropometric measurements.

    • Main Results:

    • Gamma-glutamyl transpeptidase (GGT) was the most sensitive marker, with all patients showing elevated levels by week 4 of IVN.
    • Elevated alkaline phosphatase was prolonged beyond week 9, while most other abnormalities were transient.
    • Major sepsis doubled the incidence of abnormal LFTs. Significant bilirubin rise occurred only with >8 units of blood transfusion. Pre-existing malnutrition increased the likelihood of LFT abnormalities.

    Conclusions:

    • GGT is a highly sensitive indicator of liver dysfunction during IVN in surgical patients.
    • Sepsis, extensive blood transfusions, and poor nutritional status are significant risk factors for developing LFT abnormalities during IVN.
    • Monitoring LFTs, particularly GGT, is essential in surgical patients receiving IVN, especially those with risk factors.