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Intra-arterial Thrombolysis for Extremity Frostbite Decreases Digital Amputation Rates and Hospital Length of Stay
Nishant Patel1, Dhivya R Srinivasa2, Ravi N Srinivasa1
1Division of Vascular and Interventional Radiology, Department of Radiology, University of Michigan Health System, Michigan Medicine, 1500 East Medical Center Drive, Ann Arbor, MI, 48109, USA.
Cardiovascular and Interventional Radiology
|July 14, 2017
Summary
Intra-arterial thrombolysis significantly reduced digital amputation and hospital stays for severe frostbite patients. This treatment offers a promising approach for limb salvage in cold-related injuries.
Area of Science:
- Medical research
- Vascular surgery
- Emergency medicine
Background:
- Severe frostbite poses a significant risk of digital amputation and prolonged hospitalization.
- Current management strategies for severe frostbite vary, with limited evidence on optimal interventions.
Purpose of the Study:
- To compare intra-arterial thrombolysis with non-thrombolytic management for severe frostbite.
- To evaluate the impact on digital amputation rates and hospital length of stay (LOS).
Main Methods:
- Retrospective analysis of 17 severe frostbite patients (2000-2017).
- Eight patients received intra-arterial thrombolysis (tissue plasminogen activator, heparin, and other agents).
- Nine patients received non-thrombolytic management as a control group.
Main Results:
- Intra-arterial thrombolysis group: 15% digital amputation rate, 14-day average hospital LOS.
- Control group: 77% digital amputation rate, 38-day average hospital LOS.
- Treatment group showed significantly lower amputation rates (p=0.003) and LOS (p=0.011).
Conclusions:
- Intra-arterial thrombolysis is effective in reducing digital amputation rates in severe frostbite.
- This intervention also significantly decreases hospital length of stay.
- Intra-arterial thrombolysis represents a valuable therapeutic option for severe frostbite management.
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