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Updated: Feb 26, 2026
11:00
Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
Published on: September 18, 2017
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Protein kinase C and cardiac dysfunction: a review.
Raphael M Singh1,2, Emanuel Cummings3, Constantinos Pantos4
1School of Forensic and Applied Sciences, University of Central Lancashire, Preston, England, PR1 2HE, UK. Raphael_singh@yahoo.com.
Heart Failure Reviews
|July 14, 2017
Summary
Heart failure (HF) involves the heart
Area of Science:
- Cardiology
- Molecular Biology
- Biochemistry
Background:
- Heart failure (HF) is a major global health issue, causing significant mortality and morbidity.
- Cardiac remodeling (CD) is a key process in HF pathogenesis, involving structural and functional changes in the heart.
- Protein kinase C (PKC) isozymes are critical regulators of cardiac cell signaling, growth, and function.
Purpose of the Study:
- To review the structure, functions, and distribution of PKC isozymes in healthy and diseased human hearts.
- To emphasize the role and regulation of PKC in the context of heart failure.
Main Methods:
- Literature review of existing research on PKC in cardiovascular disease.
- Focus on studies examining PKC in human hearts, both healthy and failing.
Main Results:
- PKC plays a central role in regulating cardiac processes like hypertrophy and signal transduction.
- PKC activation is implicated in the pathophysiology of various cardiovascular diseases.
- Limited data exists on PKC in human hearts, highlighting a knowledge gap.
Conclusions:
- Understanding PKC's role in the human heart is crucial for deciphering heart failure mechanisms.
- Further research into PKC regulation in heart failure is warranted to identify potential therapeutic targets.
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