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The neutrophil-lymphocyte ratio in children with atopic dermatitis: a case-control study
1Pediatrician and Pediatric Allergist University of Health Sciences, Zeynep Kamil Health Training and Research Center, Department of Pediatrics, Istanbul, Turkey.
Insights
The neutrophil-lymphocyte ratio (NLR) did not differ between children with atopic dermatitis (AD) and controls. However, NLR was higher in severe AD cases and correlated with disease severity.
Area of Science:
- Immunology
- Pediatrics
- Dermatology
Background:
- The neutrophil-lymphocyte ratio (NLR) is a recognized marker for inflammation.
- Its role in atopic dermatitis (AD) has not been previously investigated.
Purpose of the Study:
- To explore the association between NLR and clinical manifestations in children with AD.
- To determine if NLR can serve as a biomarker for AD severity.
Main Methods:
- Sixty-six children diagnosed with AD and 66 healthy children were enrolled.
- Complete blood counts, immunoglobulin E (IgE) levels, and skin prick tests were performed.
- Patients with AD were stratified based on SCORAD index into mild, moderate, and severe groups.
Main Results:
- No significant difference in NLR was observed between children with AD and the control group.
- NLR was significantly elevated in children with severe AD compared to those with mild AD.
- SCORAD scores showed a weak positive correlation with NLR, eosinophil-lymphocyte ratio, and house dust mite sensitivity.
Conclusions:
- NLR does not appear to be a distinguishing factor between AD patients and healthy controls.
- NLR levels correlate with AD severity, suggesting its potential as a prognostic indicator.
- House dust mite sensitivity and eosinophil-lymphocyte ratio also correlate with AD severity.
Background:
Neutrophil-lymphocyte ratio(NLR) is a novel marker for the evaluation of inflammation and has not been evaluated previously in patients with AD.
Objective:
To investigate the relationship between NLR and the clinical findings of AD.
Methods:
Sixty-six children with AD were included in the study.The control group was included 66 children who have no allergic and chronic diseases.The immunoglobulin(Ig)E levels and complete blood count were measured. Skin prick tests were performed using the same antigens for all patients.
Results:
NLR was not significant between the patient and control groups (p>0.05).The patients with AD were divided into 3 groups according to their SCORAD score as mild, moderate and severe AD.No statistically significant difference was present between groups in terms of demographic and clinical characteristics,eosinohil-lymphocyte ratio,eosinophil-neutrophil ratio,the percentage of eosinophil, IgE,the sensitivity of skin tests(p>0.05). However,NLR and sensitivity to house dust mite were significantly different among groups(respectively,p=0.037,p:0.043).SCORAD scores were weak positively correlated with NLR levels,eosinophil-lymphocyte ratio and the sensitivity of house dust mite (respectively,r:0.329;p:0.007,r:0.264;p:00035,r:0.325;p:0.008).
Conclusions:
We didn't found significant difference in term of mean NLR betweeen patients with AD and control group. NLR was found significantly higher in severe AD patients than mild AD patients.The house dust mite sensitivity, eosinohil-lymphocyte ratio and NLR were correlated with AD severity.
