Chronic Obstructive Pulmonary Disease and Hepatitis C
Evgeni V Mekov1, Rosen E Petkov1, Dimitar T Kostadinov1
1Clinical Center for Pulmonary Diseases, St. Sofi a Hospital for Pulmonary Diseases, Medical University of Sofi a, Sofi a, Bulgaria
Folia Medica
|July 14, 2017
Summary
Hepatitis C virus (HCV) infection is linked to a higher prevalence and faster progression of chronic obstructive pulmonary disease (COPD). This review explores the connection between these conditions and their impact on lung health.
Area of Science:
- Pulmonology
- Hepatology
- Infectious Diseases
Background:
- Chronic obstructive pulmonary disease (COPD) presents with extrapulmonary manifestations.
- Hepatitis C virus (HCV) infection is associated with extrahepatic manifestations.
- COPD patients exhibit a higher prevalence of HCV, and HCV patients show increased COPD prevalence and progression.
Purpose of the Study:
- To review the literature on the prevalence of HCV in COPD patients and vice versa.
- To examine the pathogenetic links between COPD and HCV infection.
- To understand the consequences of the co-existence of COPD and HCV.
Main Methods:
- Literature review.
- Analysis of epidemiological data.
- Examination of pathogenetic mechanisms.
Main Results:
- HCV infection contributes to the development and accelerated progression of COPD.
- HCV infection has long-term effects on lung tissue.
- The presence of HCV is associated with faster lung function decline in COPD patients, particularly smokers.
- COPD may be an extrahepatic manifestation of HCV infection.
Conclusions:
- There is a significant bidirectional relationship between COPD and HCV infection.
- HCV infection is an independent risk factor for COPD development and progression.
- Further research is warranted to elucidate the clinical implications and management strategies for patients with both conditions.
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