[Structural and hormonal alterations in the pancreas after hepatectona in dogs]

Humoral factors in the portal blood have often been suggested to play an important role in hepatic regeneration after hepatectomy. However, the correlation among insulin, glucagon and somatostatin, and islet cells of Langerhans has not been studied. Forty percent hepatectomy was carried out in dogs and intravenous glucose administration (0.5 g/kg) was the function of the pancreas to release one week after and one month after surgery to estimate administered intravenously before surgery, the plasma insulin, glucagon and somatostatin. In addition, islet cells of Langerhans were investigated with PAP technique. The following results were obtained. Alterations of carbohydrate metabolism developed as a result of portal plasma insulin deficiency one week after surgery, but granules in B cells were demonstrated as much as preoperatively. It was suggested that hypersomatostatinemia suppressed insulin release from B cells. Alterations of carbohydrate metabolism was restored to normal and portal plasma insulin response was increased one month after surgery. These indicate that hepatic regeneration after hepatectomy may contribute to these changes. Islets cell of Langerhans were hypertrophic and particularly, D cells were increased after surgery.