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Sofosbuvir based treatment of chronic hepatitis C genotype 3 infections-A Scandinavian real-life study

Olav Dalgard1,2, Ola Weiland3, Geir Noraberg4

  • 1Akershus University Hospital, Lørenskog, Norway.

Plos One
|July 14, 2017
PubMed

Insights

Sofosbuvir-based regimens achieve over 90% sustained virological response in patients with advanced liver disease due to hepatitis C virus genotype 3 infection. This real-world Scandinavian study confirms high efficacy for challenging HCV cases.

Area of Science:

  • Hepatology
  • Virology
  • Clinical Medicine

Background:

  • Hepatitis C virus (HCV) genotype 3 with advanced liver disease presents significant treatment challenges.
  • Real-world data on sofosbuvir-based regimens for this population are crucial.

Purpose of the Study:

  • To assess the effectiveness of sofosbuvir-based treatments for HCV genotype 3 in a Scandinavian real-life setting.
  • To evaluate sustained virological response (SVR12) rates in patients with advanced liver disease.

Main Methods:

  • Retrospective analysis of 316 patients with HCV genotype 3 across 16 Scandinavian centers.
  • Patients received various sofosbuvir-containing regimens (SOF+RBV, SOF+DCV, SOF+peg-IFN-α, SOF/LDV) for 12-24 weeks.
  • Fibrosis assessed by biopsy or elastography; SVR12 was the primary endpoint.

Main Results:

  • An overall SVR12 rate of 91% (284/311) was achieved in the modified intention-to-treat population.
  • Treatment regimens showed similar efficacy, but lower rates were observed in men (p=0.042) and patients with decompensated liver disease (p=0.004).
  • The majority of patients had advanced liver disease, including cirrhosis (compensated and decompensated).

Conclusions:

  • Sofosbuvir-based treatment demonstrates high efficacy (over 90% SVR) in real-world settings for HCV genotype 3 with advanced liver disease.
  • These findings support the use of sofosbuvir regimens for difficult-to-treat HCV cases.
  • Further research may explore factors influencing treatment outcomes in specific patient subgroups.
Abstract

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