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Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
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Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates

Published on: February 27, 2016

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Sirtuins in Skin and Skin Cancers

Liz Mariely Garcia-Peterson1, Melissa Jean Wilking-Busch, Mary Ann Ndiaye

  • 1Department of Dermatology, University of Wisconsin, Madison, WI, USA.

Skin Pharmacology and Physiology
|July 14, 2017
PubMed

Insights

Sirtuins, NAD+-dependent proteins, are key regulators of skin health, influencing aging, UV damage, and wound repair. They show promise as therapeutic targets for various skin conditions, from cosmetic aging to melanoma.

Area of Science:

  • Biochemistry
  • Dermatology
  • Molecular Biology

Background:

  • Sirtuins are NAD+-dependent histone deacetylases involved in cellular processes.
  • These proteins play critical roles in skin-relevant functions like aging and UV damage.
  • Emerging research highlights sirtuin involvement in skin diseases, including cancers.

Purpose of the Study:

  • To review the roles of sirtuins in skin-specific cellular functions.
  • To discuss the implications of sirtuins in skin health and disease.
  • To explore sirtuins as potential therapeutic targets for dermatological conditions.

Main Methods:

  • Literature review of studies on sirtuins and skin biology.
  • Analysis of sirtuin involvement in aging, UV response, oxidative stress, and wound repair.
  • Examination of sirtuin roles in melanoma and nonmelanoma skin cancers.

Main Results:

  • Sirtuins are integral to skin aging, UV damage response, oxidative stress, and wound healing.
  • Specific sirtuins are implicated in the pathogenesis of various skin diseases.
  • The literature suggests sirtuins are crucial for maintaining skin health.

Conclusions:

  • Sirtuins are vital regulators of skin cellular processes.
  • Targeting sirtuins offers potential for managing cosmetic skin aging.
  • Sirtuins represent promising therapeutic targets for treating skin cancers like melanoma.
Keywords:
Histone deacetylasesSirtuinsSkin

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