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Biodistribution and clearance of magnetoelectric nanoparticles for nanomedical applications using energy dispersive
Ali Hadjikhani1,2, Alexa Rodzinski3, Ping Wang1
1Department of Electrical & Computer Engineering, Florida International University, Miami, FL, USA.
Aim:
The biodistribution and clearance of magnetoelectric nanoparticles (MENs) in a mouse model was studied through electron energy dispersive spectroscopy.
Materials & Methods:
This approach allows for detection of nanoparticles (NPs) in tissues with the spatial resolution of scanning electron microscopy, does not require any tissue-sensitive staining and is not limited to MENs.
Results:
The size-dependent biodistribution of intravenously administrated MENs was measured in vital organs such as the kidneys, liver, spleen, lungs and brain at four different postinjection times including 1 day, 1 week, 4 and 8 weeks, respectively.
Conclusion:
The smallest NPs, 10-nm MENs, were cleared relatively rapidly and uniformly across the organs, while the clearance of the larger NPs, 100- and 600-nm MENs, was highly nonlinear with time and nonuniform across the organs.
