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Published on: August 2, 2016
Mannosylated liposomes improve therapeutic effects of paclitaxel in colon cancer models
Menghua Xiong1, Qian Lei1, Xinyu You2
1a Lab of Chemistry , Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center , Chengdu , P.R. China.
Abstract:
Mannose receptor (MR) is a highly effective endocytic receptor. It is closely related to tumour immune escape and metastasis. We found that MR was highly expressed in some colon cancer cell lines such as CT26 and HCT116 cells. Therefore, MR might be a potential target in colon cancer therapy. In this study, we aimed to develop mannosylated liposomes containing anticancer drug paclitaxel and investigate the potential effects on targeted therapy for colon cancer. Mannosylated liposomes were prepared by film dispersion method. Characterisation, drug release behaviour, cytotoxicity, cellular uptake, anti-tumour efficacy and safety profiles of liposomes were investigated. The results showed that mannosylated liposomes had a higher CT26 cells uptake efficiency and tumour inhibition rate, which might be due to the target effect to MR. And no notable toxicity was observed. Taken together, these data demonstrated that mannosylated liposomes could target colon cancer and improve the efficacy of chemotherapy.
Insights
Mannose receptor targeted liposomes loaded with paclitaxel show promise for colon cancer therapy. These mannosylated liposomes enhanced drug delivery and efficacy while demonstrating minimal toxicity.
Area of Science:
- Oncology
- Nanotechnology
- Pharmacology
Background:
- Mannose receptor (MR) is implicated in tumor immune escape and metastasis.
- High MR expression is observed in colon cancer cell lines (CT26, HCT116).
- MR presents a potential therapeutic target for colon cancer.
Purpose of the Study:
- To develop mannosylated liposomes encapsulating paclitaxel.
- To evaluate the efficacy of these liposomes in targeted colon cancer therapy.
- To assess drug release, cellular uptake, anti-tumor activity, and safety.
Main Methods:
- Liposomes were prepared using the film dispersion method.
- Characterization included drug release studies, cytotoxicity assays, and cellular uptake analysis.
- In vivo anti-tumor efficacy and safety profiles were investigated.
Main Results:
- Mannosylated liposomes exhibited enhanced cellular uptake in CT26 cells.
- A higher tumor inhibition rate was observed, attributed to MR targeting.
- No significant toxicity was detected, indicating a favorable safety profile.
Conclusions:
- Mannosylated liposomes effectively target colon cancer cells.
- This targeted approach improves the efficacy of paclitaxel chemotherapy.
- Mannosylated liposomes represent a promising strategy for colon cancer treatment.
