Related Experiment Video
Updated: Feb 26, 2026
Studying Orthodontic Tooth Movement in Mice
Published on: August 2, 2024
An evaluation and comparison of myeloperoxidase enzymatic activity during initial orthodontic alignment: an in vivo
Asma Fatima1, Ashok Kumar Talapaneni1, Abdul Saleh1
1a Department of Orthodontics & Dentofacial Orthopedics , Al-Badar Rural Dental College & Hospital Gulbarga , Gulbarga , Karnataka , India.
Introduction:
Tooth movement during orthodontic treatment is possible because of mechanical force-induced inflammation and remodelling in the periodontal ligament. Variation in the inflammatory response might be anticipated with initial aligning archwires of different composition. Myloperoxidase (MPO) is an enzyme found in neutrophil granules that represents an important marker of inflammation. The aim of this study was to measure MPO enzyme activity during initial alignment with orthodontic arch wires of different alloy types.
Materials And Methods:
MPO activity was determined in gingival crevicular fluid (GCF) from a sample of 60 patients divided into three groups during initial orthodontic alignment with three types of arch wire (0.016-inch superelastic (SE) NiTi; 0.016-inch heat-activated (HANT) NiTi and 0.00175-inch multistranded stainless steel). MPO activity was measured at baseline, 2 hours, 7 and 14 days after appliance activation.
Results:
MPO activity was significantly increased in GCF at 2 hours (P < 0.01), 7 and 14 days in all groups compared to baseline. Enzymatic activity was highest in the SE NiTi group followed by HANT and multistranded stainless steel groups but with no significant difference between SE NiTi and HANT groups.
Conclusion:
SE and HANT NiTi arch wires produce an increased inflammatory response based upon MPO activity during initial levelling and alignment compared to multistranded stainless steel.
