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Community-Based Lifestyle Intervention in Patients With Coronary Artery Disease: The RESPONSE-2 Trial

Madelon Minneboo1, Sangeeta Lachman1, Marjolein Snaterse2

  • 1Department of Cardiology, Academic Medical Center, Amsterdam, the Netherlands.

Journal of the American College of Cardiology
|July 15, 2017
PubMed

Insights

Combining community lifestyle programs with hospital care significantly improved lifestyle risk factors in coronary artery disease patients. Partner involvement further enhanced success rates in this randomized trial.

Area of Science:

  • Cardiology
  • Public Health
  • Behavioral Science

Background:

  • Lifestyle-related risk factors (LRFs) significantly impact cardiovascular morbidity and mortality in coronary artery disease (CAD) patients.
  • Modifying these LRFs presents a substantial clinical challenge.
  • Effective strategies are crucial for secondary prevention in CAD.

Purpose of the Study:

  • To assess the effectiveness of integrating community-based lifestyle programs with standard hospital-based secondary prevention.
  • To evaluate the impact of nurse-coordinated referrals to lifestyle interventions on LRFs in CAD patients.

Main Methods:

  • A randomized controlled trial involving 824 patients admitted for acute coronary syndrome or revascularization with at least one LRF.
  • Intervention group received nurse-coordinated referrals to community programs for weight reduction, physical activity, and smoking cessation.
  • Control group received guideline-based usual care. Primary outcome was LRF improvement at 12 months.

Main Results:

  • The intervention group showed a significantly higher success rate (37%) compared to the control group (26%) (p=0.002).
  • Success was defined as improvement in weight, physical activity, or smoking cessation.
  • Partner participation in the intervention group was linked to a greater success rate (46% vs. 34%; p=0.03).

Conclusions:

  • Nurse-coordinated referral to community-based lifestyle interventions effectively improves LRFs in CAD patients.
  • The integration of widely available lifestyle programs enhances secondary prevention efforts.
  • Optional partner participation amplifies the success of these lifestyle interventions.
Abstract

Keywords:
RESPONSE-2comprehensive lifestyle interventioncoronary artery diseasehealth behaviorimprovement of physical activitynurse-coordinated caresecondary preventionsmoking cessationweight reduction

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