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Polymorphisms in sex steroid receptors: From gene sequence to behavior
1Department of Psychology, 36 Eagle Row, Emory University, Atlanta, GA 30322, USA.
Frontiers in Neuroendocrinology
|July 15, 2017
Summary
Genetic variants in sex steroid receptors influence human behavior and mental health. This review explores how these genetic changes affect receptor function and suggests methods for further research into behavioral mechanisms.
Area of Science:
- Neuroendocrinology
- Behavioral Genetics
- Molecular Biology
Background:
- Sex steroid receptors are implicated in human behaviors and mental disorders.
- Candidate gene studies have linked androgen and estrogen receptor variants to behavioral phenotypes.
- Many identified polymorphisms are non-coding, complicating mechanistic understanding.
Purpose of the Study:
- To review associations between sex steroid receptor polymorphisms and human behavioral phenotypes.
- To explore potential mechanisms by which genetic variation affects receptor function.
- To propose methods for testing hypotheses about these mechanisms.
Main Methods:
- Review of existing literature on sex steroid receptor polymorphisms and behavior.
- Discussion of molecular mechanisms including mRNA transcription, splicing, and stability.
- Suggestion of experimental approaches like in vitro assays and animal models.
Main Results:
- Numerous genetic variants in sex steroid receptors are associated with human behavioral phenotypes.
- Non-coding polymorphisms present challenges in determining functional impact.
- Understanding mechanisms requires integrating genetic findings with molecular and cellular biology.
Conclusions:
- Genetic variations in sex steroid receptors offer insights into behavioral and mental health predispositions.
- Further research is needed to elucidate the functional consequences of these polymorphisms.
- A combination of genetic, molecular, and animal model studies is crucial for advancing mechanistic understanding.
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