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Updated: Feb 26, 2026
08:25
Identification of Circular RNAs using RNA Sequencing
Published on: November 14, 2019
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Recent progress in circular RNAs in human cancers.
Guanqun Huang1, Shuaihu Li1, Nuo Yang2
1Shenzhen Key Laboratory of Translational Medicine of Tumor, Department of Cell Biology and Genetics, Shenzhen University Health Sciences Center, Shenzhen, Guangdong, China.
Cancer Letters
|July 15, 2017
Summary
Circular RNAs (circRNAs) are novel RNA molecules with key roles in gene regulation and cellular functions. Their dysregulation in cancer suggests potential as diagnostic and prognostic biomarkers.
Area of Science:
- Molecular Biology
- Genomics
- Cancer Research
Background:
- Circular RNAs (circRNAs) are covalently closed RNA loops abundant in mammalian cells.
- Their functions include transcriptional/splicing regulation, miRNA sponging, and protein translation.
Purpose of the Study:
- To review the formation, properties, and functions of circRNAs.
- To focus on circRNA research progress in cancer, including regulation and clinical relevance.
Main Methods:
- Literature review of recent studies on circRNAs.
- Analysis of RNA sequencing (RNA-seq) data for circRNA expression in cancer.
Main Results:
- CircRNA expression is dysregulated across various cancer types (cell lines, tissues, plasma).
- Altered circRNA levels correlate with clinical characteristics, indicating roles in tumor progression.
Conclusions:
- CircRNAs show promise as biomarkers for early cancer diagnosis and prognosis.
- Their conserved sequences and stable structures support their biomarker potential.
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