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Interferon related pericarditis: Review

Kazuaki Nishio1, Tsutomu Arase1, Hiroko Tada1

  • 1Kazuaki Nishio, Tsutomu Arase, Hiroko Tada, Hideaki Tachibana, Department of Internal Medicine, Matsui Hospital, Tokyo 145-0082, Japan.

World Journal of Cardiology
|July 15, 2017
PubMed
Abstract

Insights

Interferon-related pericarditis, a rare side effect, requires early recognition and discontinuation of interferon treatment. Management involves steroids or nonsteroidal anti-inflammatory drugs.

Area of Science:

  • Cardiology
  • Oncology
  • Immunology

Background:

  • Interferon therapy is associated with various side effects.
  • Pericarditis, inflammation of the pericardium, can be a rare complication.
  • Understanding interferon-related pericarditis is crucial for patient management.

Purpose of the Study:

  • To review existing literature on interferon-related pericarditis.
  • To identify characteristics, mechanisms, and treatment outcomes.

Main Methods:

  • Systematic search of MEDLINE, EMBASE, Cinahl, and Cochrane Database.
  • Keywords: "interferon" and "pericarditis".
  • Inclusion of eligible case reports.

Main Results:

  • Nine case reports were analyzed.
  • Common symptoms included chest pain and dyspnea.
  • Mechanisms involved autoimmune responses and cardiotoxicity.
  • Treatment focused on interferon discontinuation, steroids, and NSAIDs.

Conclusions:

  • Interferon-related pericarditis is an uncertain but recognized adverse event.
  • Early diagnosis and cessation of interferon are key.
  • Steroids and NSAIDs are common treatment modalities.
Keywords:
Chronic hepatitis CChronic myelogeneous leukemiaInterferonMalignant lymphomaPericarditis

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