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Interferon related pericarditis: Review.
Kazuaki Nishio1, Tsutomu Arase1, Hiroko Tada1
1Kazuaki Nishio, Tsutomu Arase, Hiroko Tada, Hideaki Tachibana, Department of Internal Medicine, Matsui Hospital, Tokyo 145-0082, Japan.
World Journal of Cardiology
|July 15, 2017
Summary
Interferon-related pericarditis, a rare side effect, requires early recognition and discontinuation of interferon treatment. Management involves steroids or nonsteroidal anti-inflammatory drugs.
Area of Science:
- Cardiology
- Oncology
- Immunology
Background:
- Interferon therapy is associated with various side effects.
- Pericarditis, inflammation of the pericardium, can be a rare complication.
- Understanding interferon-related pericarditis is crucial for patient management.
Purpose of the Study:
- To review existing literature on interferon-related pericarditis.
- To identify characteristics, mechanisms, and treatment outcomes.
Main Methods:
- Systematic search of MEDLINE, EMBASE, Cinahl, and Cochrane Database.
- Keywords: "interferon" and "pericarditis".
- Inclusion of eligible case reports.
Main Results:
- Nine case reports were analyzed.
- Common symptoms included chest pain and dyspnea.
- Mechanisms involved autoimmune responses and cardiotoxicity.
- Treatment focused on interferon discontinuation, steroids, and NSAIDs.
Conclusions:
- Interferon-related pericarditis is an uncertain but recognized adverse event.
- Early diagnosis and cessation of interferon are key.
- Steroids and NSAIDs are common treatment modalities.
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