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Related Experiment Videos

[Opiate receptors].

L Latasch, R Christ

    Der Anaesthesist
    |February 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Opioids interact with receptors, but clinical effects vary. The multiple receptor theory explains these diverse opioid effects, linking pharmacology to clinical practice.

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    Area of Science:

    • Pharmacology
    • Neuroscience
    • Clinical Medicine

    Context:

    • The traditional receptor theory posits a single opiate receptor for all opioid interactions.
    • Clinical observations reveal a wide spectrum of effects among commonly used opioids.
    • This discrepancy challenges the basic receptor theory's explanatory power.

    Purpose:

    • To reconcile the basic receptor theory with observed clinical variations in opioid effects.
    • To introduce and explain the multiple receptor theory.
    • To connect recent pharmacological findings with practical clinical consequences of opioid use.

    Summary:

    • The basic receptor theory predicts uniform opioid effects due to interaction with a single opiate receptor.
    • Clinical practice demonstrates diverse opioid effects, contradicting the single receptor model.

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  • The multiple receptor theory, proposed by Gilbert and Martin, offers an explanation for these varied clinical outcomes.

    • Impact:

    • Provides a framework for understanding the diverse pharmacological profiles of opioids.
    • Helps clinicians better predict and manage patient responses to different opioids.
    • Facilitates the development of novel analgesics with more targeted effects.