A catalytic chiral gel microfluidic reactor assembled via dynamic covalent chemistry
Haoliang Liu1, Juan Feng1, Jianyong Zhang1
1MOE Laboratory of Bioinorganic and Synthetic Chemistry , MOE Key Laboratory of Polymeric Composite and Functional Materials , Lehn Institute of Functional Materials , School of Chemistry and Chemical Engineering , Sun Yat-Sen University , Guangzhou , 510275 , China . Email: zhjyong@mail.sysu.edu.cn ;
Abstract:
A novel dynamic covalent gel strategy is reported to immobilize an asymmetric catalyst within the channels of a microfluidic flow reactor. A layer of a catalytically active Mn-salen dynamic covalent imine gel matrix was coated onto a functionalized capillary. Mn-salen active moiety was incorporated into dynamic covalent imine gel matrix via the reaction of a chiral Mn-salen dialdehyde unit with a tetraamine linker. The catalytic activity of the capillary reactor has been demonstrated in enantioselective kinetic resolution of secondary alcohols.
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