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Related Concept Videos

Hypertension I: Introduction01:28

Hypertension I: Introduction

1.0K
Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
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Blood Pressure01:24

Blood Pressure

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The movement of blood in a human body, commonly referred to as blood flow, is determined by the volume of blood that traverses a certain section of the bodily system per unit time. It is the rhythmic contraction of the heart's ventricles that primarily instigates this movement. As the ventricles contract, blood is forced into the prominent arteries, which then flow from areas of greater pressure to lower pressure areas. This movement continues into smaller arteries and arterioles and...
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Blood Pressure01:30

Blood Pressure

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Blood pressure (BP) is the pressure or force of blood exerted on the artery's walls as it circulates through the body. It is essential for maintaining blood flow throughout the body.
The average BP in an adult is typically around 120/80 mmHg (millimeters of mercury). In this measurement, the numerator (120) indicates the systolic pressure, which is the pressure in the arteries during the contraction of the heart's ventricles as blood is expelled. The denominator (80) represents the...
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Assessment of blood pressure in brachial artery(one-step method)01:15

Assessment of blood pressure in brachial artery(one-step method)

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This procedural guide systematically measures blood pressure using an oscillometric digital sphygmomanometer, emphasizing accuracy, patient safety, and comfort.
Prepare for the Procedure:
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Factors affecting Blood pressure01:28

Factors affecting Blood pressure

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Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
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Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

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Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
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Related Experiment Video

Updated: Feb 26, 2026

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
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Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

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The Elusive Search for Optimal Blood Pressure Targets.

Alan H Gradman1

  • 1Temple University School of Medicine, 1239 Shady Avenue, Pittsburgh, PA, 15232, USA. gradmanmd@aol.com.

Current Hypertension Reports
|July 15, 2017
PubMed
Summary

Blood pressure (BP) treatment targets are re-evaluated. A systolic BP >160 mmHg requires treatment, while 140/90 mmHg remains a reasonable target for most patients. Lower targets are still debated.

Keywords:
Antihypertensive therapyBP treatment goalsBlood pressureHypertension

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Area of Science:

  • Cardiology
  • Hypertension Management
  • Clinical Trials

Background:

  • Current blood pressure (BP) treatment thresholds, like JNC-7's <140/90 mmHg and <130/80 mmHg for specific conditions, are being re-evaluated.
  • Recent meta-analyses, retrospective studies, and randomized clinical trials (RCTs) have provided new data on optimal BP targets.

Purpose of the Study:

  • To review and synthesize current evidence on blood pressure treatment targets.
  • To provide recommendations for initiating and intensifying hypertension treatment based on updated data.

Main Methods:

  • Review of meta-analyses and retrospective studies on BP treatment.
  • Analysis of findings from major randomized clinical trials, including the Action to Control Cardiovascular Risk in Diabetes (ACCORD) and Systolic Blood Pressure Intervention Trial (SPRINT).

Main Results:

  • The ACCORD trial found no superiority of systolic BP (SBP) <120 mmHg over <140 mmHg in diabetics.
  • The SPRINT trial demonstrated a 25% cardiovascular event reduction with a lower SBP target in a different population.
  • SBP >160 mmHg should generally be treated; 140/90 mmHg remains a reasonable target for identifying treatable risk in most patients.

Conclusions:

  • The 140/90 mmHg target is appropriate for most patients, including high-risk individuals with diabetes, chronic kidney disease (CKD), and/or coronary artery disease (CAD).
  • The benefit of initiating or intensifying treatment for BPs in the 130s remains uncertain.
  • Future research should focus on standardizing BP measurement and conducting RCTs for SBP <130 mmHg in specific patient groups.