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Related Concept Videos

Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Interactions Between Signaling Pathways01:19

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Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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Molecular Factors Affecting Cell Division01:27

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Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
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Once a ligand binds to a receptor, the signal is transmitted through the membrane and into the cytoplasm. The continuation of a signal in this manner is called signal transduction. Signal transduction only occurs with cell-surface receptors, which cannot interact with most components of the cell, such as DNA. Only internal receptors can interact directly with DNA in the nucleus to initiate protein synthesis. When a ligand binds to its receptor, conformational changes occur that affect the...
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Related Experiment Video

Updated: Feb 26, 2026

Generation and Expansion of Human Cardiomyocytes from Patient Peripheral Blood Mononuclear Cells
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Generation and Expansion of Human Cardiomyocytes from Patient Peripheral Blood Mononuclear Cells

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Cardiomyocyte proliferation: remove brakes and push accelerators.

Lingjuan He1, Bin Zhou1,2

  • 1The State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.

Cell Research
|July 15, 2017
PubMed
Summary
This summary is machine-generated.

Adult hearts struggle to repair after injury because heart cells (cardiomyocytes) don't multiply. New research explores removing cell cycle blockers and using drugs to boost cardiomyocyte proliferation for cardiac regeneration.

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Area of Science:

  • Cardiovascular Biology
  • Regenerative Medicine
  • Cellular Cardiology

Background:

  • Adult mammalian hearts exhibit limited cardiomyocyte proliferation post-injury, hindering natural repair.
  • Cardiomyocyte cell cycle arrest is a key barrier to cardiac regeneration.
  • Therapeutic strategies targeting cardiomyocyte proliferation are crucial for treating heart damage.

Purpose of the Study:

  • To explore novel therapeutic avenues for cardiac regeneration.
  • To investigate methods for overcoming cardiomyocyte cell cycle arrest.
  • To present recent advancements in promoting heart repair after injury.

Main Methods:

  • Review of recent publications in high-impact journals (Nature, Cell Research).
  • Analysis of strategies involving cell cycle blocker removal.
  • Evaluation of pharmacological approaches to enhance cardiomyocyte proliferation.

Main Results:

  • Identification of promising approaches to stimulate cardiomyocyte division.
  • Evidence suggesting potential for significant cardiac repair.
  • Highlighting recent breakthroughs in the field.

Conclusions:

  • Recent studies offer new hope for treating heart injuries.
  • Targeting cardiomyocyte proliferation is a viable strategy for cardiac regeneration.
  • Further research in this area could revolutionize cardiovascular medicine.