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New insights into sinusoidal obstruction syndrome.
Andrea Piccin1,2,3, Maria T Sartori4, Gianni Bisogno5
1Transfusion Service, San Maurizio Regional Hospital, Bolzano, Italy.
Internal Medicine Journal
|July 15, 2017
Summary
This study reveals that endothelial extracellular vesicles (EV) CD144+ and plasminogen-activator inhibitor type 1 (PAI-1) may serve as biomarkers for sinusoidal obstruction syndrome (SOS). Findings suggest a procoagulant and hypofibrinolytic state in SOS, potentially benefiting from anticoagulant therapy.
Area of Science:
- Hematology
- Vascular Biology
- Oncology
Background:
- Sinusoidal obstruction syndrome (SOS) is a serious complication following hematopoietic stem cell transplantation and chemotherapy.
- This study investigated patients diagnosed with SOS between 2000 and 2011.
Purpose of the Study:
- To explore the relationship between endothelial extracellular vesicles (EV) and plasminogen-activator inhibitor type 1 (PAI-1) in the early stages of SOS.
- To assess modifications in EV and PAI-1 levels during SOS development.
Main Methods:
- Blood samples from SOS patients and controls were analyzed for cell-derived EV, PAI-1 levels (antigen and activity), and coagulation parameters.
- Statistical analysis was performed to identify significant correlations between all measured variables.
Main Results:
- SOS patients exhibited reduced antithrombin levels and platelet counts, indicative of consumption.
- PAI-1 levels showed an inverse correlation with platelet counts and were inversely related to specific EV markers (EV CD144+, EV CD31+/CD41+).
- Increased EV CD144+, associated with gap junction rupture, were observed in SOS patients.
Conclusions:
- The study indicates a procoagulant and hypofibrinolytic state in SOS, suggesting potential benefits of anticoagulant therapy.
- Endothelial extracellular vesicles (EV) CD144+ and PAI-1 are proposed as potential novel biomarkers for diagnosing and monitoring SOS.
Keywords:
PAI-1:AgPAI-1:actextracellular vesiclesinusoidal obstruction syndromeveno-occlusive diseaseMore Related Videos
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