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Updated: Feb 26, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
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Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates

Published on: February 27, 2016

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Emerging Roles for SIRT5 in Metabolism and Cancer

Lauren R Bringman-Rodenbarger1, Angela H Guo1, Costas A Lyssiotis2

  • 11 Department of Pathology, University of Michigan , Ann Arbor, Michigan.

Antioxidants & Redox Signaling
|July 15, 2017
PubMed
Abstract

Insights

Sirtuin 5 (SIRT5) plays a key role in cancer metabolic reprogramming by modifying proteins involved in cellular metabolism. Further research is needed to fully understand SIRT5

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cancer Research

Background:

  • Sirtuin 5 (SIRT5) is a NAD+-dependent lysine deacetylase.
  • SIRT5 modifies protein targets involved in metabolism within mitochondria and other cellular compartments.
  • Emerging evidence links SIRT5 to metabolic reprogramming, a hallmark of cancer.

Purpose of the Study:

  • To summarize the biological functions of SIRT5 in normal and cancerous tissues.
  • To discuss potential mechanisms of SIRT5's impact on tumorigenesis via metabolic reprogramming.
  • To review current pharmacological strategies targeting SIRT5.

Main Methods:

  • Literature review and synthesis of existing research on SIRT5.
  • Analysis of SIRT5's role in key metabolic pathways.
  • Discussion of SIRT5's implications in cancer development.

Main Results:

  • SIRT5 is implicated in regulating glycolysis, the TCA cycle, fatty acid oxidation, and nitrogen metabolism.
  • SIRT5 influences antioxidant defense and apoptosis.
  • SIRT5's substrates and interactors are still not fully characterized.

Conclusions:

  • SIRT5 is a significant regulator of metabolic reprogramming in cancer.
  • Further investigation into SIRT5's functions and targets is crucial for understanding its role in normal and neoplastic cells.
  • Targeting SIRT5 presents a potential therapeutic avenue in cancer treatment.
Keywords:
SIRT5deglutarylasedemalonylasedesuccinylasemetabolic reprogrammingsirtuins

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