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Design rules for combined label-free and fluorescence Bloch surface wave biosensors
Optics Letters
|July 15, 2017
Summary
This study fabricated novel optical biosensors using Bloch surface waves. High-quality factor designs do not always improve biosensor performance, revealing key conditions for optimal biochip design.
Area of Science:
- Photonics and Biosensing
- Materials Science
Background:
- Optical biosensors are crucial for label-free and fluorescence detection.
- Bloch surface waves (BSWs) at photonic crystal interfaces offer unique sensing capabilities.
Purpose of the Study:
- To fabricate and characterize optical biosensors utilizing BSWs for simultaneous label-free and fluorescence detection.
- To investigate the impact of photonic crystal resonance finesse on biosensor performance.
Main Methods:
- Fabrication of two types of 1D photonic crystals on organic substrates with micro-optics.
- Characterization of BSW resonances with high and low finesse.
- Testing biosensors on a common optical readout system.
Main Results:
- Experimental results indicate that a high resonance quality factor (finesse) does not guarantee improved biosensor performance in practical applications.
- Performance was evaluated for biosensors with differing BSW resonance characteristics.
Conclusions:
- Optimal biochip design is critical and not solely dependent on maximizing resonance quality factor.
- Conditions for the effective operation of the complete bio-sensing platform were established.
