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Microbial characteristics of post-traumatic infective keratitis
Blanche X Lim1, Victor T C Koh1,2, Manotosh Ray1,2
11 Department of Ophthalmology, National University Health System, Singapore - Singapore.
European Journal of Ophthalmology
|July 15, 2017
Summary
Post-traumatic infective keratitis in Singapore predominantly affects males due to work-related injuries. Gram-negative bacteria, particularly Pseudomonas aeruginosa, are common, necessitating broader antibiotic coverage in tropical regions.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Microbiology
Background:
- Post-traumatic infective keratitis is a significant cause of vision loss.
- Understanding causative pathogens and risk factors is crucial for effective management.
Purpose of the Study:
- To investigate the demographics, risk factors, clinical and microbiological features, and treatment outcomes of post-traumatic infective keratitis.
- To inform treatment guidelines, especially in tropical regions.
Main Methods:
- Prospective study of 26 patients with post-traumatic infective keratitis (excluding contact lens-related cases) at a Singapore tertiary hospital.
- Data collected included demographics, injury type, microbiological diagnosis, antibiotic sensitivity, and treatment outcomes.
Main Results:
- The majority of patients were male and sustained work-related injuries.
- Gram-negative organisms, especially Pseudomonas aeruginosa, were the predominant isolates.
- Most infections resolved with medical treatment, but some required corneal transplantation.
Conclusions:
- Empirical treatment for post-traumatic infective keratitis in tropical countries should include Gram-negative coverage.
- Reinforcing work safety practices and early physician education is essential.
