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Related Experiment Videos

Internal reference standards in ionic regulation and the predictability of ionic concentrations in animals.

R F Burton

    Comparative Biochemistry and Physiology. A, Comparative Physiology
    |January 1, 1986
    PubMed
    Summary

    Internal reference standards help regulate ion concentrations within species. These standards likely involve cell membrane properties and may not exist for all concentrations like osmolality.

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    Area of Science:

    • Biochemistry
    • Cell Biology
    • Physiology

    Background:

    • Species exhibit remarkably consistent internal ion concentrations.
    • The mechanisms and existence of internal reference standards for these concentrations are poorly understood.

    Purpose of the Study:

    • To explore the concept of internal reference standards for ionic concentrations.
    • To identify potential properties related to these standards, such as cell membrane characteristics.

    Main Methods:

    • Conceptual analysis of ion regulation in biological systems.
    • Review of existing literature on cellular potentials, charge densities, and equilibrium constants.

    Main Results:

    • Internal reference standards are proposed to explain consistent ion concentrations across individuals.

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  • Cell membrane properties (potentials, charge densities, equilibrium constants) are likely involved.
  • Solubility may influence specific ion products, like calcium and carbonate.
  • Some concentrations, such as osmolality, may lack direct reference standards.

    • Conclusions:

    • Internal reference standards are crucial for maintaining physiological homeostasis.
    • Further research is needed to identify and characterize these standards and their molecular basis.
    • The concept highlights the complex interplay between cellular properties and systemic ion balance.