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Related Concept Videos

Electrodes: Overview01:17

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 Electrochemical measurements are conducted in an electrochemical cell composed of various components that control and measure the current and potential. One fundamental component is electrodes, conductive materials that enable electron transfer reactions at their surfaces.
There are two main types of electrodes in electrochemical cells. The first type, known as the working or indicator electrode, has a potential that is sensitive to the analyte's concentration and reacts to changes in...
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Related Experiment Video

Updated: Feb 26, 2026

Neonatal Pial Surface Electroporation
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Electroporation by concentric-type needle electrodes and arrays.

Yi Kung1, Alexey Lihachev2, Saulius Šatkauskas3

  • 1Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei city, Taiwan; National Taiwan University College of Medicine, Taipei city, Taiwan.

Bioelectrochemistry (Amsterdam, Netherlands)
|July 15, 2017
PubMed
Summary

Concentric-type needle electrodes offer a safer, more precise method for gene transfer in genomic medicine. This novel approach minimizes tissue damage and improves usability for enhanced therapeutic outcomes.

Keywords:
Adult zebrafishElectroporationGene deliveryGene therapyGenomic medicineTransfection

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Area of Science:

  • Biomedical Engineering
  • Genomic Medicine
  • Electrophysiology

Background:

  • Gene transfer efficiency is crucial for genomic medicine.
  • Electroporation is a promising physical gene transfer method.
  • Current electroporation techniques face challenges in electrical safety, tissue damage, and invasiveness.

Purpose of the Study:

  • To propose a novel method using concentric-type needle electrodes for gene transfer.
  • To address the limitations of conventional electroporation.
  • To enhance electrical safety, human factors, and usability in genomic medicine.

Main Methods:

  • Development and application of concentric-type needle electrodes.
  • Utilizing a low bias voltage (10V).
  • Minimizing the working area to approximately 10mm³ for precision.

Main Results:

  • The proposed method offers improved electrical safety.
  • Reduced tissue damage and fewer required wounds.
  • Enhanced accuracy, precision, and usability through a smaller working area and fewer steps.
  • Potential for simultaneous treatment of multiple target regions through needle arraying.

Conclusions:

  • Concentric-type needle electrodes represent a significant advancement in gene transfer technology.
  • This novel approach enhances the safety, efficiency, and applicability of genomic medicine.
  • The method holds promise for improving patient outcomes and expanding the use of gene therapies.