Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

An update on tardive dyskinesia.

G M Simpson, E H Pi, J J Sramek

    Hospital & Community Psychiatry
    |April 1, 1986
    PubMed
    Summary

    Tardive dyskinesia is a severe movement disorder linked to neuroleptic medications. Current management focuses on dopamine receptor sensitivity, with prevention through careful prescribing and monitoring being key.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Abscisic acid associated with wilting in dwarf and tall Pisum sativum.

    Planta·2014
    Same author

    Efficacy and safety of sibutramine for weight loss in obese patients with hypertension well controlled by beta-adrenergic blocking agents: a placebo-controlled, double-blind, randomised trial.

    Journal of human hypertension·2002
    Same author

    Pharmacokinetics and tolerability of buspirone during oral administration to children and adolescents with anxiety disorder and normal healthy adults.

    Journal of clinical pharmacology·2002
    Same author

    Considerations in choosing an antidepressant.

    Psychiatric services (Washington, D.C.)·2001
    Same author

    Pharmacokinetic-pharmacodynamic modeling of rivastigmine, a cholinesterase inhibitor, in patients with Alzheimer's disease.

    Journal of clinical pharmacology·2001
    Same author

    Psychopharmacology: rational and irrational polypharmacy.

    Psychiatric services (Washington, D.C.)·2001

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Movement Disorders

    Background:

    • Tardive dyskinesia (TD) is a serious, persistent movement disorder.
    • It is frequently associated with long-term neuroleptic treatment.
    • Dopamine receptor supersensitivity is the hypothesized cause.

    Purpose of the Study:

    • To review current research on tardive dyskinesia.
    • To cover its definition, diagnosis, and underlying mechanisms.
    • To discuss treatment, management, and risk factors.

    Main Methods:

    • Literature review of recent research.
    • Analysis of neuropathophysiology and treatment strategies.
    • Examination of risk factors and preventive measures.

    Main Results:

    • Dopamine receptor supersensitivity is implicated in TD.
    • Treatments include dopamine receptor blockade and depletion.
    • Newer neuroleptics may have lower TD risk.
    • Preventive strategies are crucial.

    Conclusions:

    • Careful neuroleptic prescription and monitoring are vital for preventing TD.
    • Gradual tapering of neuroleptics can mitigate risk.
    • Clinicians must remain vigilant for TD symptoms.

    Related Experiment Videos