Fungal immunomodulatory protein-fve could modulate airway remodel through by affect IL17 cytokine

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Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice

Published on: February 18, 2015

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Yu-Tzu Lee1, Chia-Ta Wu2, Hai-Lun Sun3

  • 1Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
|July 16, 2017
PubMed
Abstract

Insights

FIP-fve effectively reduced airway remodeling and inflammation in a chronic asthma model. This compound suppressed inflammatory cells, Th2 cytokines, and Th17 cells, offering potential as an alternative therapy for allergic airway diseases.

Area of Science:

  • Immunology
  • Respiratory Medicine
  • Pharmacology

Background:

  • Asthma is a prevalent allergic disease.
  • Previous research indicated FIP-fve reduces inflammation and balances Th1/Th2 in acute models.
  • The impact of FIP-fve on airway remodeling in chronic asthma remained unexplored.

Purpose of the Study:

  • To investigate the efficacy of orally administered FIP-fve in reducing airway remodeling in chronic allergic asthma models.
  • To evaluate FIP-fve's effects on airway inflammation, Th1/Th2 balance, and specific inflammatory markers.

Main Methods:

  • A chronic asthma model was established in Balb/c mice using ovalbumin (OVA) challenges.
  • Airway inflammation and hyperresponsiveness (AHR) were assessed using a BUXCO system.
  • Bronchoalveolar lavage fluid (BALF), serum, and lung tissues were analyzed for inflammatory cells, cytokines, collagen deposition, and matrix metalloproteinase 9 (MMP9) expression.

Main Results:

  • FIP-fve significantly reduced inflammatory cell infiltration (neutrophils, eosinophils) and Th2 cytokines while increasing Th1 cytokines in BALF and serum.
  • Compared to corticosteroids, FIP-fve demonstrated superior reduction of infiltrating cells.
  • Oral FIP-fve suppressed IL-17 and enhanced IL-22, decreased MMP9 expression, collagen deposition, and overall airway remodeling.

Conclusions:

  • FIP-fve exhibits significant anti-inflammatory effects in OVA-induced airway inflammation.
  • FIP-fve inhibits Th17 cells, leading to reduced airway remodeling and collagen expression.
  • FIP-fve presents as a promising alternative therapeutic agent for allergic airway diseases.
Keywords:
Airway remodelingAsthmaCollagen depositionFIP-fveIL-17IL-22

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