Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

1.3K
This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
1.3K
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

7.1K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
7.1K
Maxam-Gilbert Sequencing01:05

Maxam-Gilbert Sequencing

13.2K
In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
Challenges of the Maxam-Gilbert Method
The...
13.2K
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

8.3K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
8.3K
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

3.8K
3.8K
Genetic Drift03:33

Genetic Drift

44.4K
Natural selection—probably the most well-known evolutionary mechanism—increases the prevalence of traits that enhance survival and reproduction. However, evolution does not merely propagate favorable traits, nor does it always benefit populations.
44.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Atypical wet AMD].

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·2016
Same author

Safety, pharmacokinetics and pharmacodynamics of the anti-hepcidin Spiegelmer lexaptepid pegol in healthy subjects.

British journal of pharmacology·2016
Same author

Pharmacological characteristics of a novel, recombinant fusion protein linking coagulation factor VIIa with albumin (rVIIa-FP).

Journal of thrombosis and haemostasis : JTH·2014
Same author

Renal Ewing tumors.

Annals of oncology : official journal of the European Society for Medical Oncology·2013
Same author

Hematopoietic stem and progenitor cell mobilization in mice and humans by a first-in-class mirror-image oligonucleotide inhibitor of CXCL12.

Clinical pharmacology and therapeutics·2013
Same author

Improved kinetics of rIX-FP, a recombinant fusion protein linking factor IX with albumin, in cynomolgus monkeys and hemophilia B dogs.

Journal of thrombosis and haemostasis : JTH·2012

Related Experiment Video

Updated: Feb 26, 2026

A Concoction Pipeline for Generating Molecular Operational Taxonomic Units (MOTUs) Among Riparian and Aquatic Beetles
10:23

A Concoction Pipeline for Generating Molecular Operational Taxonomic Units (MOTUs) Among Riparian and Aquatic Beetles

Published on: July 11, 2025

722

An efficient algorithm for generating the internal branches of a Kingman coalescent.

M Reppell1, S Zöllner2

  • 1Department of Human Genetics, University of Chicago, Chicago, IL, USA.

Theoretical Population Biology
|July 16, 2017
PubMed
Summary

This study introduces a faster method for simulating genealogies by analytically calculating internal branch properties. This approach is at least 10 times faster than traditional coalescent simulations for estimating key population genetics statistics.

Keywords:
CoalescentCoalescent simulationsGenealogical topology

More Related Videos

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin
08:57

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin

Published on: August 14, 2018

16.6K
Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.8K

Related Experiment Videos

Last Updated: Feb 26, 2026

A Concoction Pipeline for Generating Molecular Operational Taxonomic Units (MOTUs) Among Riparian and Aquatic Beetles
10:23

A Concoction Pipeline for Generating Molecular Operational Taxonomic Units (MOTUs) Among Riparian and Aquatic Beetles

Published on: July 11, 2025

722
Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin
08:57

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin

Published on: August 14, 2018

16.6K
Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.8K

Area of Science:

  • Population genetics
  • Computational biology
  • Evolutionary genetics

Background:

  • Coalescent simulations are standard for modeling sample genealogies.
  • Full simulations become computationally intensive with large sample sizes.
  • Estimating statistics based on internal branch lengths typically requires full simulations.

Purpose of the Study:

  • To develop an efficient method for sampling limited portions of genealogies.
  • To enable accurate estimation of statistics reliant on internal branch length distributions.
  • To overcome the computational burden of full coalescent simulations.

Main Methods:

  • Developed a sampling method using analytic equations for internal branch probabilities.
  • Equations determine branch number, start, and end, conditional on subtended samples.
  • Method avoids direct simulation of coalescent waiting times.

Main Results:

  • The new method efficiently generates partial genealogies.
  • Achieved equivalent distributions of branch lengths and summary statistics compared to full simulations.
  • Demonstrated a speed improvement of at least 10x under various conditions.

Conclusions:

  • The proposed analytic sampling method offers a computationally efficient alternative to full coalescent simulations.
  • This advancement facilitates the study of complex population genetic models with large datasets.
  • The method provides a faster way to estimate statistics crucial for understanding evolutionary processes.