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Updated: Feb 26, 2026

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
Association of thrombomodulin c.1418C>T polymorphism and venous thromboembolism
Bei Hu1, Qing-Yun Wang2, Liang Tang1
1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China; Collaborative Innovation Center of Hematology, Huazhong University of Science and Technology, Wuhan, China.
Objectives:
To investigate the association between thrombomodulin c.1418C>T polymorphism and venous thrombosis.
Methods:
Systematic searches of Pubmed, EMBASE, Chinese Biomedical Database, Chinese National Knowledge Infrastructure, the VIP Database and WANFANG Database were performed. Pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated to assess the strength of the association. Subgroup analysis was conducted to seek for potential sources of heterogeneity.
Results:
A total of 8 studies were collected in our analysis, including 2519 cases and 3196 controls. No significant association between thrombomodulin c.1418C>T polymorphism and venous thrombosis was shown under the five genetic models (T vs C: OR=1.02, 95% CI=0.82-1.26; TT vs CC: OR=0.90, 95% CI=0.52-1.56; CT vs CC: OR=1.07, 95% CI=0.84-1.37; CT+TT vs CC: OR=1.05, 95% CI=0.82-1.34; TT vs CT+CC: OR=0.81, 95% CI=0.59-1.11). Similar results were observed in the following subgroup analysis based on ethnicity and source of control. However, an increased risk of venous thrombosis was found in Asian populations under three genetic models (T vs C: OR=1.31, 95% CI=1.01-1.70; CT vs CC: OR=1.41, 95% CI=1.00-2.98; TT+CT vs CC vs CC: OR=1.41, 95% CI=1.02-1.95).
Conclusion:
Current studies on the thrombomodulin c.1418C>T polymorphism are of great heterogeneity. It might not be a risk factor for venous thromboembolism.
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