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Updated: Feb 26, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
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For whom does interpersonal psychotherapy work? A systematic review.

Samantha L Bernecker1, Alice E Coyne1, Michael J Constantino1

  • 1Department of Psychological and Brain Sciences, University of Massachusetts, Tobin Hall, 135 Hicks Way, Amherst, MA 01003-9271, USA.

Clinical Psychology Review
|July 16, 2017
PubMed
Summary

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A coparent intervention to prevent prenatal stress and depression symptoms in families with lower incomes.

Family relations·2026
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Does attachment change serve as a theory-specific mediator of depression reduction in interpersonal psychotherapy versus cognitive behavioral therapy?

Psychotherapy research : journal of the Society for Psychotherapy Research·2026
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Are some therapists more effective when they deliver one type of therapy versus another?

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Efficacy and moderators of cognitive behavioural therapy versus interpersonal psychotherapy for adult depression: study protocol of a systematic review and individual participant data meta-analysis.

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Patients' race/ethnicity in relation to their experiences of and attitudes toward therapist referral/assignment.

Cogent mental health·2025

Interpersonal psychotherapy (IPT) shows varied effectiveness. Few patient characteristics consistently predict when IPT is superior to other treatments for depression and related disorders.

Area of Science:

  • Psychiatry and Psychology
  • Clinical Trials Research

Background:

  • Interpersonal psychotherapy (IPT) is an established treatment for depression.
  • Identifying patient subgroups that benefit most from IPT compared to other therapies remains unclear.

Purpose of the Study:

  • To review 46 years of clinical trial research.
  • To identify patient characteristics that moderate the relative efficacy of IPT versus alternative treatments.

Main Methods:

  • Systematic review of 57 studies from 33 clinical trials.
  • Comparison of IPT against pharmacotherapy, other psychotherapies, and control conditions.

Main Results:

  • Few consistent moderators identified for IPT's relative efficacy.
  • IPT may outperform school counseling for adolescents with interpersonal conflict.
Keywords:
Aptitude-treatment interactionInterpersonal psychotherapyModeratorPersonalized medicine

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  • IPT may be superior to minimal controls for severe depression.
  • Cognitive-behavioral therapy may be more effective for avoidant personality disorder symptoms.
  • Preliminary evidence suggests IPT benefits certain age groups, African-American patients, and those in an index depression episode.
  • Conclusions:

    • Identifying moderators of IPT efficacy is challenging due to study limitations.
    • Low statistical power and heterogeneity contribute to difficulties in identifying consistent moderators.
    • Future research should consider within-subjects designs, single treatment ingredient manipulation, and power-enhancing strategies.