Preeclampsia: Pathogenesis, Prevention, and Long-Term Complications.

Area of Science:

• Reproductive Medicine
• Obstetrics
• Vascular Biology

Background:

• Preeclampsia affects 5-8% of pregnancies globally, causing significant maternal and fetal morbidity/mortality.
• The exact pathogenesis remains unclear, but an imbalance in angiogenic factors is implicated in its clinical manifestations and risk factors.

Purpose of the Study:

• To review the role of angiogenic factors in preeclampsia pathogenesis and complications.
• To discuss the utility of angiogenic markers for disease prediction and risk stratification.
• To explore therapeutic strategies aimed at restoring angiogenic balance and summarize preventive measures and long-term outcomes.

Main Methods:

• Literature review focusing on the role of angiogenic factors in preeclampsia.
• Analysis of studies on angiogenic markers as biomarkers.
• Examination of therapeutic interventions targeting angiogenic balance in animal and human studies.

Main Results:

• Imbalance in angiogenic factors is central to preeclampsia development and complications.
• Angiogenic markers show potential for predicting and risk-stratifying preeclampsia.
• Therapeutic strategies aim to correct angiogenic imbalance, with ongoing research into prevention and long-term cardiovascular health.

Conclusions:

• Angiogenic factors are critical in preeclampsia pathogenesis and management.
• Biomarkers and targeted therapies hold promise for improving preeclampsia outcomes.
• Further research is needed on prevention and the long-term cardiovascular health of affected women.