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Updated: Feb 26, 2026

Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow

Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow

Published on: March 17, 2023

Manufacturing Cell Therapies Using Engineered Biomaterials.

Amr A Abdeen¹, Krishanu Saha²

¹Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA.

Trends in Biotechnology

|July 17, 2017

Summary

This summary is machine-generated.

Engineered biomaterials offer a promising approach to control cell manufacturing for regenerative therapies. These smart materials can guide cell behavior, ensuring standardized and safe clinical applications.

Keywords:

biomanufacturing biomaterials cell therapies gene editing immunotherapy regenerative medicine reprogramming stem cells

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Area of Science:

Biomaterials Science
Regenerative Medicine
Cell Manufacturing

Background:

Advanced therapies rely on precise cell engineering, involving genomic and epigenomic manipulation.
Controlling cell manufacturing is crucial for the safety and efficacy of clinical trials.

Purpose of the Study:

To review the application of engineered biomaterials in controlling human cell manufacturing.
To highlight the potential of biomaterials in standardizing cell production for clinical use.

Main Methods:

Discussion of engineered biomaterials with tunable properties.
Analysis of how these materials influence cell stemness, differentiation, reprogramming, and phenotype selection.

Main Results:

Engineered biomaterials can provide cues to guide cell behavior during manufacturing.
Smart biomaterials offer a versatile tool for cell manipulation and selection.

Conclusions:

Engineered biomaterials are key to developing standardized cell manufacturing processes.
Future research can leverage biomaterials to produce cells with defined critical quality attributes for clinical testing.