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Infection or Glioma? The False Dilemma of Primary Central Nervous System Histiocytic Sarcoma
William Clifton1, Oluwaseun Oluwadara Akinduro1, Sebastian Lopez-Chiriboga1
1Department of Neurological Surgery, Mayo Clinic Florida, Jacksonville, Florida, USA.
Background:
Primary central nervous system (CNS) histiocytic sarcoma is an extremely rare lymphoproliferative disorder that affects the CNS and behaves aggressively. Only 27 cases of primary CNS histiocytic sarcoma have been reported. The paucity of literature on this entity has made diagnosis and treatment difficult both for the surgeon and the pathologist.
Case Description:
In this case of primary CNS histiocytic sarcoma, a middle-aged woman presented from an outside institution with a supposed cerebellar abscess. Intraoperative frozen pathology was initially interpreted as high-grade glioma; however, final pathology demonstrated histiocytic sarcoma.
Conclusions:
This report makes a significant contribution to the literature on this rare malignant disease by outlining a similar presentation among several cases and providing a thorough overview of existing criteria for diagnosis and management.
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