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Polyalkyl cyanoacrylate nanocapsules.

M S el-Samaligy, P Rohdewald, H A Mahmoud

    The Journal of Pharmacy and Pharmacology
    |March 1, 1986
    PubMed
    Summary
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    Researchers developed novel nanocapsules using methyl, ethyl, and butyl cyanoacrylates for drug delivery. These nanocapsules effectively encapsulated markers and controlled their release, with higher monomer concentrations slowing release rates.

    Area of Science:

    • Polymer Chemistry
    • Nanotechnology
    • Materials Science

    Background:

    • Cyanoacrylate monomers are versatile for polymerization.
    • Nanoparticle drug delivery systems offer controlled release benefits.
    • Interfacial polymerization is a key technique for nanocapsule fabrication.

    Purpose of the Study:

    • To synthesize and characterize nanocapsules using methyl cyanoacrylate (MCA), ethyl cyanoacrylate (ECA), and butyl cyanoacrylate (BCA).
    • To evaluate the encapsulation efficiency and in-vitro release kinetics of marker substances (fluorescein, doxorubicin).
    • To investigate the impact of monomer concentration on nanocapsule properties and drug release.

    Main Methods:

    • In-situ interfacial polymerization of MCA, ECA, and BCA in a water-in-oil emulsion.

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  • Characterization using electron microscopy and particle size analysis.
  • Assessment of marker holding capacity and in-vitro release studies.

    • Main Results:

    • Nearly spherical nanocapsules (500-1500 nm) were successfully prepared with all three monomers.
    • Encapsulation efficiencies ranged from 55-74% for the marker substances.
    • Marker release was progressively retarded from MCA, ECA, to BCA nanocapsules; higher monomer concentrations further slowed release.

    Conclusions:

    • MCA, ECA, and BCA are suitable for preparing drug-loaded nanocapsules via interfacial polymerization.
    • Nanocapsule properties, including drug release rate, can be tuned by monomer choice and concentration.
    • These findings support the potential of cyanoacrylate nanocapsules for controlled drug delivery applications.