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Related Concept Videos

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Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
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Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
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Related Experiment Video

Updated: Feb 26, 2026

Resting-State Connectivity and Neuroimaging of Prefrontal Cortex Activity During a Block-Design Yoga Asana Practice Using fNIRS
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Resisting Sleep Pressure: Impact on Resting State Functional Network Connectivity.

Laura Tüshaus1,2,3, Joshua Henk Balsters4, Anthony Schläpfer2,5

  • 1Chronobiology and Sleep Research, Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.

Brain Topography
|July 17, 2017
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Summary

Sleep restriction increases sleep pressure, impacting brain function. Longer wakefulness alters functional network connectivity (FNC) between resting-state networks (RSNs), potentially impairing information transfer and indicating reduced consciousness.

Keywords:
Arterial spin labelingBOLDCerebral blood flowImaging modalityIndependent component analysisPseudo BOLDTime awakeVigilance

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Sleep Research

Background:

  • Sleep restriction is prevalent, leading to increased sleep pressure and potential cognitive impairment.
  • Resting-state network (RSN) analysis is a valuable tool for studying brain function under varying vigilance levels.
  • Investigating the effects of sleep pressure on RSNs using different imaging modalities is crucial for understanding brain function.

Purpose of the Study:

  • To investigate the impact of increased sleep pressure on resting-state networks (RSNs).
  • To assess the suitability of cerebral blood flow (CBF) and pseudo-BOLD signals for deriving RSNs.
  • To examine changes in functional network connectivity (FNC) under conditions of high sleep pressure.

Main Methods:

  • Examined RSNs in participants with normal (10h awake) and high (19h awake) sleep pressure.
  • Utilized three imaging modalities: arterial spin labeling (ASL), BOLD fMRI, and pseudo-BOLD.
  • Applied independent component analysis (ICA) to derive RSNs and analyzed FNC.

Main Results:

  • CBF and pseudo-BOLD signals derived from ASL are suitable for ICA-based RSN analysis.
  • Increased sleep pressure significantly altered FNC between RSNs, particularly the default mode network.
  • Specific FNC changes, including increased anti-correlation and within-network alterations in sensorimotor networks, were observed with longer wakefulness.

Conclusions:

  • Functional network connectivity changes reflect compensatory mechanisms against sleepiness and early signs of reduced consciousness.
  • Altered FNC suggests impaired information transfer between brain networks due to sleep pressure.
  • The study highlights the sensitivity of FNC to sleep pressure and its potential as a biomarker for cognitive impairment.