Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

462
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
462
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

282
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
282
Mitral Valve Prolapse III: Nursing Management01:19

Mitral Valve Prolapse III: Nursing Management

471
The nursing management of Mitral Valve Prolapse, or MVP, centers around patient education, symptom monitoring, and lifestyle modifications.Patient Education on MVP Diagnosis and Heredity: Nurses should provide comprehensive education about MVP, a condition where the mitral valve does not close appropriately during heartbeats. This education often includes the condition's pathophysiology, symptoms, and potential complications, like arrhythmias or mitral regurgitation. Though not fully...
471
Menopause01:28

Menopause

5.1K
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
5.1K
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

764
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
764
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

4.0K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Low-dose aspirin reduces placental inflammation and restores angiogenic balance in a rat model of excessive hypercholesterolemia in pregnancy.

American journal of physiology. Heart and circulatory physiology·2026
Same author

Gestational diabetes exposure in utero is associated with increased aortic stiffness in older children.

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme·2026
Same author

Regulatory T cells and decidual vascular remodelling - A new piece in the preeclampsia puzzle.

Journal of reproductive immunology·2026
Same author

Excessive hypercholesterolemia in pregnancy impairs the cardiovascular health of the adult female and male offspring.

Bioscience reports·2026
Same author

miR-155 suppresses angiotensin II type 1 receptor synthesis during placental morphogenesis.

Cell death discovery·2025
Same author

Pharmacological increases in circulating ketones fail to alleviate the hypertrophic cardiomyopathy present in the Tafazzin knockdown mouse model of Barth syndrome.

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques·2025
Same journal

Physiological load and breath-holding in artistic swimming: a scoping review establishing historical baselines and evidence gaps in the context of the 2022-2025 rule changes.

Frontiers in physiology·2026
Same journal

Effects of blood flow restriction exercise interventions on patellofemoral pain syndrome: a systematic review and meta-analysis.

Frontiers in physiology·2026
Same journal

Effects of resistance-type and cycling-type high-intensity interval training on cardiorespiratory fitness, lower-body strength, and anaerobic fitness.

Frontiers in physiology·2026
Same journal

Model-based estimates of sex differences in peak power and fatigue index in track cyclists using directed acyclic graphs, inverse probability of treatment weighting, and Bayesian modeling.

Frontiers in physiology·2026
Same journal

Fine-tuning striated muscle performance: conserved sarcomere-level mechanisms across insect and vertebrate systems.

Frontiers in physiology·2026
Same journal

Effects of different dual-task trainings on gait and cortical activation during obstacle crossing in stroke patients: a randomized controlled trial.

Frontiers in physiology·2026
See all related articles

Related Experiment Video

Updated: Feb 26, 2026

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
06:55

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

Published on: December 5, 2015

14.2K

Advanced Maternal Age Worsens Postpartum Vascular Function.

Jude S Morton1,2, Alison S Care1,2, Raven Kirschenman1,2

  • 1Department of Obstetrics and Gynaecology, University of AlbertaEdmonton, AB, Canada.

Frontiers in Physiology
|July 18, 2017
PubMed
Summary
This summary is machine-generated.

Advanced maternal age increases cardiovascular risks. Studies in aged rats show pregnancy loss causes distinct vascular pathology, while postpartum rats exhibit vascular dysfunction, highlighting risks for later-life cardiovascular disease.

Keywords:
advanced maternal agepostpartumpregnancy lossprostaglandinvascular function

More Related Videos

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis
06:19

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis

Published on: January 7, 2018

10.9K
Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System
07:34

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System

Published on: May 5, 2018

12.4K

Related Experiment Videos

Last Updated: Feb 26, 2026

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
06:55

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

Published on: December 5, 2015

14.2K
A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis
06:19

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis

Published on: January 7, 2018

10.9K
Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System
07:34

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System

Published on: May 5, 2018

12.4K

Area of Science:

  • Cardiovascular Science
  • Reproductive Biology
  • Aging Research

Background:

  • Increasing maternal age is linked to adverse cardiovascular outcomes.
  • Pregnancy complications at advanced maternal age predict future cardiovascular issues.
  • Aging itself is an independent risk factor for cardiovascular disease.

Purpose of the Study:

  • To investigate the long-term vascular effects of pregnancy and pregnancy loss in aged rats.
  • To determine if advanced maternal age leads to postpartum vascular dysfunction.
  • To explore mechanisms underlying cardiovascular risks associated with advanced maternal age.

Main Methods:

  • Utilized a reproductively aged rat model.
  • Assessed vascular function in virgin, postpartum, and nulliparous (pregnancy loss) rats.
  • Measured aortic relaxation responses and analyzed receptor contributions (LOX-1) and vasodilation pathways (EDH).

Main Results:

  • Nulliparous rats (pregnancy loss) showed significantly reduced aortic relaxation compared to virgin and postpartum rats.
  • Oxidized LDL impaired relaxation in virgin and postpartum rats, with increased LOX-1 involvement in postpartum rats.
  • Postpartum rats exhibited reduced EDH-mediated vasodilation and a constrictive prostaglandin effect in mesenteric arteries.

Conclusions:

  • Aged postpartum rats displayed vascular dysfunction.
  • Rats experiencing pregnancy loss demonstrated a distinct vascular pathology.
  • These findings suggest mechanisms linking early pregnancy loss and postpartum vascular dysfunction to later-life cardiovascular disease in advanced maternal age women.