Related Experiment Video
Updated: Feb 26, 2026

Single-Molecule Imaging of Nuclear Transport
Published on: June 9, 2010
The molecular mechanism for nuclear transport and its application
Yun Hak Kim1,2,3, Myoung-Eun Han1,3, Sae-Ock Oh1,3
1Department of Anatomy, Pusan National University School of Medicine, Yangsan, Korea.
Abstract:
Transportation between the cytoplasm and the nucleoplasm is critical for many physiological and pathophysiological processes including gene expression, signal transduction, and oncogenesis. So, the molecular mechanism for the transportation needs to be studied not only to understand cell physiological processes but also to develop new diagnostic and therapeutic targets. Recent progress in the research of the nuclear transportation (import and export) via nuclear pore complex and four important factors affecting nuclear transport (nucleoporins, Ran, karyopherins, and nuclear localization signals/nuclear export signals) will be discussed. Moreover, the clinical significance of nuclear transport and its application will be reviewed. This review will provide some critical insight for the molecular design of therapeutics which need to be targeted inside the nucleus.
More Related Videos
08:46Using LEXY and LINuS Optogenetics Tools and Automated Image Analysis to Quantify Nucleocytoplasmic Transport Dynamics in Live Cells
Published on: July 22, 2025
09:12Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes
Published on: December 20, 2019
Related Concept Videos
Directionality of Nuclear Transport
Nuclear Protein Sorting
Proteins targeted to the nucleus carry nuclear localization signals or NLS recognized by import receptors in the cytosol. Similarly, proteins with nuclear export signals are recognized by export receptors. Import and export receptors are...
Regulation of Nuclear Protein Sorting
Nuclear Export
NES are of three types- the canonical 10-residue long leucine-rich signal and other...
Nuclear Localization Signals and Import
Nuclear Export of mRNA