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Updated: Oct 8, 2026

Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
Published on: September 29, 2015
Closure of Oroantral Communication Using Platelet-rich Fibrin: A Report of Two Cases
Mounzer Assad1, Waseem Bitar1, Mohammed Nasser Alhajj2
1Department of Oral Surgery, Faculty of Dentistry, Tishreen University, Lattakia, Syria.
Abstract:
Oroantral communication (OAC) is an abnormal connection between the maxillary sinus and oral cavity. It is mostly formed after the extraction of the first and second upper molars. Platelet-rich fibrin (PRF) created by Choukroun's protocol concentrates most platelets and leukocytes from a blood harvest to a single autologous fibrin biomaterial. It has been used widely in oral and maxillofacial surgery. However, no data are available concerning the use of PRF alone as a clot and a membrane for the closure of OACs. Two clinical cases presented with OAC, created after extraction of tooth #16 in two patients, were closed with PRF as a clot and a membrane and monitored until the epithelization of the sockets was ended successfully. Two months postclosure, the sockets were evaluated clinically and on waters' view radiography. The results of these case reports showed that PRF can be successfully applied for the closure of OACs.

