Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Intracellular Movement of Viruses and Bacteria

Intracellular Movement of Viruses and Bacteria

Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Respecting Patient Autonomy When Patients Refuse Treatment for Surgical Complications.

ANZ journal of surgery·2026

Same author

Intranasal infection of Rift Valley fever virus in the ferret model suggests multiple routes of neuroinvasion with consequential encephalitis and ophthalmitis.

Scientific reports·2026

Same author

Multimodality Diagnosis and Management of Carcinoid Heart Disease: Outcomes and Long-Term Follow-Up.

JACC. Case reports·2026

Same author

Environmental drivers of tick density in UK dairy farms: implications for livestock health and agri-environment policy.

Parasites & vectors·2026

Same author

Alongshan virus in the virome of Ixodes hexagonus ticks in the United Kingdom.

Ticks and tick-borne diseases·2026

Same author

Music as a scientific metaphor for mind and brain.

Neuroscience and biobehavioral reviews·2026

Same journal

Retraction: Commentary: One mechanism of Sishen Pill on diarrhea with kidney Yang deficiency syndrome: influencing metabolic function by intestinal microorganisms and enzyme activity mediates the gut-kidney axis.

Frontiers in cellular and infection microbiology·2026

Same journal

The CRISPR-Cas toolkit for mosquito-borne virus surveillance: detection, tracing, and discovery.

Frontiers in cellular and infection microbiology·2026

Same journal

Distinctive reproductive tract microbial characteristics associated with infertility in women: a systematic review and meta-analysis.

Frontiers in cellular and infection microbiology·2026

Same journal

STING agonist 2'3'-cGAMP as an effective adjuvant for HPV16 peptide vaccine enhances anti-tumor immunity in TC-1 mice models.

Frontiers in cellular and infection microbiology·2026

Same journal

Development and validation of a risk prediction model for hospital mortality in adult patients with <i>Staphylococcus aureus</i> bacteremia.

Frontiers in cellular and infection microbiology·2026

Same journal

Exploratory model-based optimizing isavuconazole dosing regimens for <i>Aspergillus</i> spp. in adult patients according to serum albumin levels: a pharmacokinetic/pharmacodynamic analysis using Monte Carlo simulation.

Frontiers in cellular and infection microbiology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 26, 2026

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Published on: July 26, 2017

Tick-Virus Interactions: Toll Sensing.

Nicholas Johnson^1,2

¹Animal and Plant Health AgencyAddlestone, United Kingdom.

Frontiers in Cellular and Infection Microbiology

|July 18, 2017

Summary

This summary is machine-generated.

Researchers are exploring how Toll signaling in ticks may detect viruses. Understanding this interaction is key to controlling tick-borne diseases and virus transmission.

Keywords:

Toll Toll-like receptors immunity ticks virus

More Related Videos

Viral Tracing of Genetically Defined Neural Circuitry

Viral Tracing of Genetically Defined Neural Circuitry

Published on: October 17, 2012

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production

Published on: March 2, 2014

Related Experiment Videos

Last Updated: Feb 26, 2026

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Published on: July 26, 2017

Viral Tracing of Genetically Defined Neural Circuitry

Viral Tracing of Genetically Defined Neural Circuitry

Published on: October 17, 2012

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production

Published on: March 2, 2014

Area of Science:

Veterinary Entomology
Virology
Immunology

Background:

Ticks are significant vectors of viral diseases affecting humans and animals.
Research has historically focused on tick-host interactions, neglecting the tick-virus relationship.
New technologies and genomic data are enabling deeper investigation into tick-pathogen interactions.

Purpose of the Study:

To investigate the role of Toll signaling in tick antiviral defense.
To understand how Toll signaling affects virus maintenance within the tick vector.
To explore the evolutionary equilibrium between ticks and tick-borne viruses.

Main Methods:

Utilizing tick-cell lines as model systems for studying tick-pathogen interactions.
Leveraging genomic data, including the Ixodes scapularis genome.
Observing the presence and potential function of conserved protein families like Toll receptors in ticks.

Main Results:

Toll and Toll-like receptors, known for microbial detection in vertebrates, have been observed in ticks.
The study aims to determine if these receptors are involved in detecting viral infections within the tick.
Further research is needed to elucidate the precise mechanisms and implications.

Conclusions:

The role of Toll signaling in tick antiviral immunity is an emerging area of research.
Understanding this pathway could reveal novel strategies for managing tick-borne viral diseases.
The tick-virus relationship may be more complex than a simple equilibrium.