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Postnatal Growth in a Cohort of Sardinian Intrauterine Growth-Restricted Infants

Maria Grazia Clemente1, Giampiero Capobianco2, Paolo Mattia Galasso1

  • 1Pediatric Clinic, Department of Surgical, Microsurgical and Medical Sciences, University of Sassari, Sassari, Italy.

Biomed Research International
|July 18, 2017
PubMed

Insights

Infants with intrauterine growth restriction (IUGR) often show significant catch-up growth in weight, length, and head circumference during their first year. This catch-up growth is crucial for their development up to the third postnatal year.

Area of Science:

  • Pediatrics
  • Neonatology
  • Human Growth and Development

Background:

  • Intrauterine growth restriction (IUGR) affects fetal development, leading to smaller infants at birth.
  • Catch-up growth is a known phenomenon in infants born with IUGR, but its extent and duration require further study.
  • Understanding postnatal growth patterns in IUGR infants is essential for monitoring and intervention.

Purpose of the Study:

  • To evaluate the postnatal growth trajectory of infants diagnosed with intrauterine growth restriction (IUGR).
  • To compare the anthropometric parameters of IUGR infants with a control group from birth to three years.
  • To determine the prevalence and timing of catch-up growth in a cohort of IUGR infants.

Main Methods:

  • An observational retrospective study involving 12 IUGR infants and 12 control infants.
  • Measurement of anthropometric parameters: weight (W), length (L), and head circumference (HC).
  • Data collection from birth up to the third postnatal year.

Main Results:

  • Significant differences in W, L, and HC were observed at birth between IUGR and control groups (p < 0.0001 for all).
  • During the first year, 70% (8/12) of IUGR infants demonstrated significant catch-up growth across all measured parameters.
  • IUGR infants who experienced catch-up growth maintained regular growth patterns until the third postnatal year.

Conclusions:

  • The majority of infants with IUGR exhibit significant catch-up growth, primarily within the first 12 months of life.
  • Postnatal growth patterns in IUGR infants are variable, with some showing catch-up and others not.
  • Further research into IUGR causes is needed for improved prevention and individualized treatment strategies.

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