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Drug Delivery and Nanoformulations for the Cardiovascular System
W J Geldenhuys1, M T Khayat1,2, J Yun3
1Department of Pharmaceutical Sciences, West Virginia University, School of Pharmacy, Morgantown WV 26506 USA.
Research & Reviews. Drug Delivery
|July 18, 2017
Summary
Developing targeted drug delivery systems for the cardiovascular system is crucial for treating diseases like hypertension. While promising, cardiovascular delivery lags behind cancer and brain research, requiring further investigation into pharmacological agents.
Area of Science:
- Cardiovascular pharmacology and drug delivery systems.
Background:
- Therapeutic delivery to the cardiovascular system is vital for treating atherosclerosis, ischemic-reperfusion injury, and hypertension.
- Current cardiovascular targeted delivery research is nascent compared to tumor or brain delivery fields.
- Understanding cardiovascular pharmacology, including receptor agonists and antagonists, is essential for effective therapeutic strategies.
Purpose of the Study:
- To review available options for developing cardiovascular delivery systems.
- To evaluate the potential of nanoparticles, peptides, and small molecules for cardiovascular therapy.
- To highlight the need for further research in targeted cardiovascular drug delivery.
Main Methods:
- Literature review of targeted delivery systems for the cardiovascular system.
- Analysis of various therapeutic agents including small organic compounds, nanoparticles, peptides, and siRNA.
- Discussion of pharmacological considerations for cardiovascular drug delivery.
Main Results:
- Cardiovascular targeted drug delivery is an emerging field with limited publications.
- Nanoproduct formulations show potential in overcoming physiological barriers.
- Effective cardiovascular delivery requires a deep understanding of pharmacology.
Conclusions:
- Targeted delivery systems offer significant potential for improving cardiovascular disease treatment.
- Further research is needed to advance cardiovascular drug delivery technologies.
- Integrating pharmacological knowledge is key to successful cardiovascular therapeutic strategies.
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